dc.contributor.author | Ji, Wang | en_US |
dc.contributor.author | Shah, Dilip | en_US |
dc.contributor.author | Chen, Xinyuan | en_US |
dc.contributor.author | Anderson, R. Rox | en_US |
dc.contributor.author | Wu, Mei X. | en_US |
dc.date.accessioned | 2015-05-04T15:27:28Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Ji, Wang, Dilip Shah, Xinyuan Chen, R. Rox Anderson, and Mei X. Wu. 2015. “A micro-sterile inflammation array as an adjuvant for influenza vaccines.” Nature communications 5 (1): 4447. doi:10.1038/ncomms5447. http://dx.doi.org/10.1038/ncomms5447. | en |
dc.identifier.issn | 2041-1723 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:15034938 | |
dc.description.abstract | There is an urgent need of adjuvants for cutaneous vaccination. Here we report that micro-sterile inflammation induced at inoculation sites can augment immune responses to influenza vaccines in animal models. The inoculation site is briefly illuminated with a handheld, non-ablative fractional laser before the vaccine is intradermally administered, which creates an array of self-healing microthermal zones (MTZs) in the skin. The dying cells in the MTZs send “danger” signals that attract a large number of antigen-presenting cells, in particular, plasmacytoid dendritic cells (pDCs) around each MTZ forming a micro-sterile inflammation array. A pivotal role for pDCs in the adjuvanticity is ascertained by significant abrogation of the immunity after systemic depletion of pDCs, local application of a TNF-α inhibitor, or null mutation of IFN regulatory factor7 (IRF7). In contrast to conventional adjuvants that cause persistent inflammation and skin lesions, micro-sterile inflammation enhances efficacy of influenza vaccines, yet with diminished adverse effects. | en |
dc.language.iso | en_US | en |
dc.relation.isversionof | doi:10.1038/ncomms5447 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391636/pdf/ | en |
dash.license | LAA | en_US |
dc.title | A micro-sterile inflammation array as an adjuvant for influenza vaccines | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature communications | en |
dash.depositing.author | Wu, Mei X. | en_US |
dc.date.available | 2015-05-04T15:27:28Z | |
dc.identifier.doi | 10.1038/ncomms5447 | * |
dash.contributor.affiliated | Wu, Mei | |