The landscape of metastatic progression patterns across major human cancers
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Author
Budczies, Jan
von Winterfeld, Moritz
Klauschen, Frederick
Bockmayr, Michael
Denkert, Carsten
Wolf, Thomas
Warth, Arne
Dietel, Manfred
Anagnostopoulos, Ioannis
Weichert, Wilko
Wittschieber, Daniel
Stenzinger, Albrecht
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.18632/oncotarget.2677Metadata
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Budczies, J., M. von Winterfeld, F. Klauschen, M. Bockmayr, J. K. Lennerz, C. Denkert, T. Wolf, et al. 2015. “The landscape of metastatic progression patterns across major human cancers.” Oncotarget 6 (1): 570-583.Abstract
The majority of patients with solid malignancies die from metastatic burden. However, our current understanding of the mechanisms and resulting patterns of dissemination is limited. Here, we analyzed patterns of metastatic progression across 16 major cancer types in a cohort of 1008 patients with metastatic cancer autopsied between 2000 and 2013 to assess cancer specific progression patterns of disease and related risk predictions. The frequency and location of metastases were evaluated in and across 1) 16 major cancers, 2) smoking- and non-smoking-related cancers and 3) adeno- and squamous cell carcinoma. Associations between primary and secondary sites were analyzed by the fractional and the relative risk methods. We detected significantly different cancer specific patterns of metastatic progression with specific relative risk profiles for secondary site involvement. Histology and smoking etiology influenced these patterns. Backward analysis showed that metastatic patterns help to predict unknown primary sites. Solid malignancies maintain a unique and recurrent organ tropism to specific secondary sites which does not appear to be strongly influenced by advances in cancer medicine as shown by comparison with previous data sets. The delineated landscape of metastatic progression patterns is a comprehensive data resource to both clinical and basic scientists which aids fostering new hypotheses for cancer research and cancer therapies.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381616/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:15034939
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