Cytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopia

DSpace/Manakin Repository

Cytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopia

Citable link to this page

 

 
Title: Cytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopia
Author: Lian, Gewei; Sheen, Volney L.

Note: Order does not necessarily reflect citation order of authors.

Citation: Lian, Gewei, and Volney L. Sheen. 2015. “Cytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopia.” Frontiers in Cellular Neuroscience 9 (1): 99. doi:10.3389/fncel.2015.00099. http://dx.doi.org/10.3389/fncel.2015.00099.
Full Text & Related Files:
Abstract: The actin cytoskeleton regulates many important cellular processes in the brain, including cell division and proliferation, migration, and cytokinesis and differentiation. These developmental processes can be regulated through actin dependent vesicle and organelle movement, cell signaling, and the establishment and maintenance of cell junctions and cell shape. Many of these processes are mediated by extensive and intimate interactions of actin with cellular membranes and proteins. Disruption in the actin cytoskeleton in the brain gives rise to periventricular heterotopia (PH), a malformation of cortical development, characterized by abnormal neurons clustered deep in the brain along the lateral ventricles. This disorder can give rise to seizures, dyslexia and psychiatric disturbances. Anatomically, PH is characterized by a smaller brain (impaired proliferation), heterotopia (impaired initial migration) and disruption along the neuroependymal lining (impaired cell-cell adhesion). Genes causal for PH have also been implicated in actin-dependent processes. The current review provides mechanistic insight into actin cytoskeletal regulation of cortical development in the context of this malformation of cortical development.
Published Version: doi:10.3389/fncel.2015.00099
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381626/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:15034940
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters