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dc.contributor.authorLian, Geweien_US
dc.contributor.authorSheen, Volney L.en_US
dc.date.accessioned2015-05-04T15:27:28Z
dc.date.issued2015en_US
dc.identifier.citationLian, Gewei, and Volney L. Sheen. 2015. “Cytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopia.” Frontiers in Cellular Neuroscience 9 (1): 99. doi:10.3389/fncel.2015.00099. http://dx.doi.org/10.3389/fncel.2015.00099.en
dc.identifier.issn1662-5102en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:15034940
dc.description.abstractThe actin cytoskeleton regulates many important cellular processes in the brain, including cell division and proliferation, migration, and cytokinesis and differentiation. These developmental processes can be regulated through actin dependent vesicle and organelle movement, cell signaling, and the establishment and maintenance of cell junctions and cell shape. Many of these processes are mediated by extensive and intimate interactions of actin with cellular membranes and proteins. Disruption in the actin cytoskeleton in the brain gives rise to periventricular heterotopia (PH), a malformation of cortical development, characterized by abnormal neurons clustered deep in the brain along the lateral ventricles. This disorder can give rise to seizures, dyslexia and psychiatric disturbances. Anatomically, PH is characterized by a smaller brain (impaired proliferation), heterotopia (impaired initial migration) and disruption along the neuroependymal lining (impaired cell-cell adhesion). Genes causal for PH have also been implicated in actin-dependent processes. The current review provides mechanistic insight into actin cytoskeletal regulation of cortical development in the context of this malformation of cortical development.en
dc.language.isoen_USen
dc.publisherFrontiers Media S.A.en
dc.relation.isversionofdoi:10.3389/fncel.2015.00099en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381626/pdf/en
dash.licenseLAAen_US
dc.subjectReviewen
dc.subjectfilaminen
dc.subjectforminen
dc.subjectRhoGTPasesen
dc.subjectactin cytoskeletonen
dc.subjectproliferationen
dc.subjectpolarityen
dc.subjectmigrationen
dc.subjectperiventricular heterotopiaen
dc.titleCytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopiaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalFrontiers in Cellular Neuroscienceen
dash.depositing.authorLian, Geweien_US
dc.date.available2015-05-04T15:27:28Z
dc.identifier.doi10.3389/fncel.2015.00099*
dash.contributor.affiliatedSheen, Volney
dash.contributor.affiliatedLian, Gewei


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