Show simple item record

dc.contributor.authorDiaz-Gil, Danielen_US
dc.contributor.authorMueller, Noomien_US
dc.contributor.authorMoreno-Duarte, Ingriden_US
dc.contributor.authorLin, Hsinen_US
dc.contributor.authorAyata, Cenken_US
dc.contributor.authorCusin, Cristinaen_US
dc.contributor.authorCotten, Joseph F.en_US
dc.contributor.authorEikermann, Matthiasen_US
dc.date.accessioned2015-05-04T15:27:41Z
dc.date.issued2014en_US
dc.identifier.citationDiaz-Gil, Daniel, Noomi Mueller, Ingrid Moreno-Duarte, Hsin Lin, Cenk Ayata, Cristina Cusin, Joseph F. Cotten, and Matthias Eikermann. 2014. “Etomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Rats.” Pharmaceuticals 8 (1): 21-37. doi:10.3390/ph8010021. http://dx.doi.org/10.3390/ph8010021.en
dc.identifier.issn1424-8247en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:15034979
dc.description.abstractWe tested the hypothesis that etomidate and ketamine produce residual effects that modify functional mobility (measured by the balance beam test) and adrenal function (adrenocorticotropic hormone (ACTH) stimulation) immediately following recovery from loss of righting reflex in rats. Intravenous etomidate or ketamine was administered in a randomized, crossover fashion (2 or 4 mg/kg and 20 or 40 mg/kg, respectively) on eight consecutive days. Following recovery of righting reflex, animals were assessed for residual effects on functional mobility on the balance beam, motor behavior in the open field and adrenal function through ACTH stimulation. We evaluated the consequences of the effects of the anesthetic agent-induced motor behavior on functional mobility. On the balance beam, etomidate-treated rats maintained their grip longer than ketamine-treated rats, indicating greater balance abilities (mean ± SD, 21.5 ± 25.1 s vs. 3.0 ± 4.3 s respectively, p < 0.021). In the open field test, both dosages of etomidate and ketamine had opposite effects on travel behavior, showing ketamine-induced hyperlocomotion and etomidate-induced hypolocomotion. There was a significant interaction between anesthetic agent and motor behavior effects for functional mobility effects (p < 0.001). Corticosterone levels were lower after both 40 mg/kg ketamine and 4 mg/kg etomidate anesthesia compared to placebo, an effect stronger with etomidate than ketamine (p < 0.001). Following recovery from anesthesia, etomidate and ketamine have substantial side effects. Ketamine-induced hyperlocomotion with 20 and 40 mg/kg has stronger effects on functional mobility than etomidate-induced hypolocomotion with 2 and 4 mg/kg. Etomidate (4 mg/kg) has stronger adrenal suppression effects than ketamine (40 mg/kg).en
dc.language.isoen_USen
dc.publisherMDPIen
dc.relation.isversionofdoi:10.3390/ph8010021en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381199/pdf/en
dash.licenseLAAen_US
dc.subjectetomidateen
dc.subjectketamineen
dc.subjectanesthesiaen
dc.subjecthyperlocomotionen
dc.subjectcoordinationen
dc.subjectadrenal functionen
dc.titleEtomidate and Ketamine: Residual Motor and Adrenal Dysfunction that Persist beyond Recovery from Loss of Righting Reflex in Ratsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPharmaceuticalsen
dash.depositing.authorAyata, Cenken_US
dc.date.available2015-05-04T15:27:41Z
dc.identifier.doi10.3390/ph8010021*
dash.contributor.affiliatedCotten, Joseph
dash.contributor.affiliatedAyata, Cenk
dash.contributor.affiliatedEikermann, Matthias
dash.contributor.affiliatedCusin, Cristina


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record