Systems approach to the study of brain damage in the very preterm newborn
Citation
Leviton, Alan, Pierre Gressens, Olaf Wolkenhauer, and Olaf Dammann. 2015. “Systems approach to the study of brain damage in the very preterm newborn.” Frontiers in Systems Neuroscience 9 (1): 58. doi:10.3389/fnsys.2015.00058. http://dx.doi.org/10.3389/fnsys.2015.00058.Abstract
Background:: A systems approach to the study of brain damage in very preterm newborns has been lacking. Methods:: In this perspective piece, we offer encephalopathy of prematurity as an example of the complexity and interrelatedness of brain-damaging molecular processes that can be initiated inflammatory phenomena. Results:: Using three transcription factors, nuclear factor-kappa B (NF-κB), Notch-1, and nuclear factor erythroid 2 related factor 2 (NRF2), we show the inter-connectedness of signaling pathways activated by some antecedents of encephalopathy of prematurity. Conclusions:: We hope that as biomarkers of exposures and processes leading to brain damage in the most immature newborns become more readily available, those who apply a systems approach to the study of neuroscience can be persuaded to study the pathogenesis of brain disorders in the very preterm newborn.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396381/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:15034996
Collections
- HMS Scholarly Articles [17723]
Contact administrator regarding this item (to report mistakes or request changes)