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dc.contributor.authorSadowski, John P.en_US
dc.contributor.authorCalvert, Colby R.en_US
dc.contributor.authorZhang, David Yuen_US
dc.contributor.authorPierce, Niles A.en_US
dc.contributor.authorYin, Pengen_US
dc.date.accessioned2015-05-04T15:27:58Z
dc.date.issued2014en_US
dc.identifier.citationSadowski, John P., Colby R. Calvert, David Yu Zhang, Niles A. Pierce, and Peng Yin. 2014. “Developmental Self-Assembly of a DNA Tetrahedron.” ACS Nano 8 (4): 3251-3259. doi:10.1021/nn4038223. http://dx.doi.org/10.1021/nn4038223.en
dc.identifier.issn1936-0851en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:15035032
dc.description.abstractKinetically controlled isothermal growth is fundamental to biological development, yet it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed assembly and disassembly pathways. By exploiting the programmable chemistry of base pairing, sophisticated spatial and temporal control have been demonstrated in DNA self-assembly, but largely as separate pursuits. By integrating temporal with spatial control, here we demonstrate the “developmental” self-assembly of a DNA tetrahedron, where a prescriptive molecular program orchestrates the kinetic pathways by which DNA molecules isothermally self-assemble into a well-defined three-dimensional wireframe geometry. In this reaction, nine DNA reactants initially coexist metastably, but upon catalysis by a DNA initiator molecule, navigate 24 individually characterizable intermediate states via prescribed assembly pathways, organized both in series and in parallel, to arrive at the tetrahedral final product. In contrast to previous work on dynamic DNA nanotechnology, this developmental program coordinates growth of ringed substructures into a three-dimensional wireframe superstructure, taking a step toward the goal of kinetically controlled isothermal growth of complex three-dimensional geometries.en
dc.language.isoen_USen
dc.publisherAmerican Chemical Societyen
dc.relation.isversionofdoi:10.1021/nn4038223en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004324/pdf/en
dash.licenseLAAen_US
dc.subjectArticleen
dc.subjectmolecular programmingen
dc.subjectDNA nanotechnologyen
dc.subjectkinetic pathway controlen
dc.subjectdevelopmental self-assemblyen
dc.titleDevelopmental Self-Assembly of a DNA Tetrahedronen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalACS Nanoen
dash.depositing.authorYin, Pengen_US
dc.date.available2015-05-04T15:27:58Z
dc.identifier.doi10.1021/nn4038223*
dash.contributor.affiliatedYin, Peng


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