Proline-Directed Androgen Receptor Phosphorylation

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Proline-Directed Androgen Receptor Phosphorylation

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Title: Proline-Directed Androgen Receptor Phosphorylation
Author: Gao, Yanfei; Chen, Shaoyong

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Citation: Gao, Yanfei, and Shaoyong Chen. 2013. “Proline-Directed Androgen Receptor Phosphorylation.” Journal of molecular and genetic medicine : an international journal of biomedical research 7 (3): 75. doi:10.4172/1747-0862.1000075.
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Abstract: The androgen receptor (AR) has been identified for decades and mediates essential steroid functions. Like most of biological molecules, AR functional activities are modulated by post-translational modifications. This review is focused on the reported activities and significance of AR phosphorylation, with particular emphasis on proline-directed serine/threonine phosphorylation that occurs predominantly on the receptor. The marked enrichment of AR phosphorylation in the most diverse N-terminal domain suggests that targeting AR phosphorylation can be synergistic to antagonizing the C-terminal domain by clinical antiandrogens.
Published Version: doi:10.4172/1747-0862.1000075
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