Proline-Directed Androgen Receptor Phosphorylation
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CitationGao, Yanfei, and Shaoyong Chen. 2013. “Proline-Directed Androgen Receptor Phosphorylation.” Journal of molecular and genetic medicine : an international journal of biomedical research 7 (3): 75. doi:10.4172/1747-0862.1000075. http://dx.doi.org/10.4172/1747-0862.1000075.
AbstractThe androgen receptor (AR) has been identified for decades and mediates essential steroid functions. Like most of biological molecules, AR functional activities are modulated by post-translational modifications. This review is focused on the reported activities and significance of AR phosphorylation, with particular emphasis on proline-directed serine/threonine phosphorylation that occurs predominantly on the receptor. The marked enrichment of AR phosphorylation in the most diverse N-terminal domain suggests that targeting AR phosphorylation can be synergistic to antagonizing the C-terminal domain by clinical antiandrogens.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:15035044
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