Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation
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Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation
| Title: | Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation |
| Author: |
Hayes, Josie; Thygesen, Helene; Droop, Alastair; Hughes, Thomas A.; Westhead, David; Lawler, Sean E.; Wurdak, Heiko; Short, Susan C.
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Hayes, Josie, Helene Thygesen, Alastair Droop, Thomas A. Hughes, David Westhead, Sean E. Lawler, Heiko Wurdak, and Susan C. Short. 2015. “Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation.” Oncoscience 2 (3): 252-262. |
| Full Text & Related Files: |
4394131.pdf (1.826Mb; PDF) 
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| Abstract: | MicroRNA expression can be exploited to define tumor prognosis and stratification for precision medicine. It remains unclear whether prognostic microRNA signatures are exclusively tumor grade and/or molecular subtype-specific, or whether common signatures of aggressive clinical behavior can be identified. Here, we defined microRNAs that are associated with good and poor prognosis in grade III and IV gliomas using data from The Cancer Genome Atlas. Pathway analysis of microRNA targets that are differentially expressed in good and poor prognosis glioma identified a link to oligodendrocyte development. Notably, a microRNA expression profile that is characteristic of a specific oligodendrocyte precursor cell type (OP1) correlates with microRNA expression from 597 of these tumors and is consistently associated with poor patient outcome in grade III and IV gliomas. Our study reveals grade-independent and subtype-independent prognostic molecular signatures in high-grade glioma and provides a framework for investigating the mechanisms of brain tumor aggressiveness. |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394131/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:15035064 |
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