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dc.contributor.authorAlim, Karen
dc.contributor.authorAmselem, G.
dc.contributor.authorPeaudecerf, F.
dc.contributor.authorBrenner, Michael P.
dc.contributor.authorPringle, Anne E.
dc.date.accessioned2015-05-18T20:36:40Z
dc.date.issued2013
dc.identifier.citationAlim, K., G. Amselem, F. Peaudecerf, M. P. Brenner, and A. Pringle. 2013. “Random Network Peristalsis in Physarum Polycephalum Organizes Fluid Flows Across an Individual.” Proceedings of the National Academy of Sciences 110 (33) (July 29): 13306–13311. doi:10.1073/pnas.1305049110.en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:15754026
dc.description.abstractIndividuals can function as integrated organisms only when information and resources are shared across a body. Signals and substrates are commonly moved using fluids, often channeled through a network of tubes. Peristalsis is one mechanism for fluid transport and is caused by a wave of cross-sectional contractions along a tube.We extend the concept of peristalsis from the canonical case of one tube to a random network. Transport is maximized within the network when the wavelength of the peristaltic wave is of the order of the size of the network. The slime mold Physarum polycephalum grows as a random network of tubes, and our experiments confirm peristalsis is used by the slime mold to drive internal cytoplasmic flows. Comparisons of theoretically generated contraction patterns with the patterns exhibited by individuals of P. polycephalum demonstrate that individuals maximize internal flows by adapting patterns of contraction to size, thus optimizing transport throughout an organism. This control of fluid flow may be the key to coordinating growth and behavior, including the dynamic changes in network architecture seen over time in an individual.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherProceedings of the National Academy of Sciencesen_US
dc.relation.isversionofdoi:10.1073/pnas.1305049110en_US
dash.licenseLAA
dc.subjectacellularen_US
dc.subjectfungien_US
dc.subjectmyxomyceteen_US
dc.titleRandom network peristalsis in Physarum polycephalum organizes fluid flows across an individualen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dash.depositing.authorPringle, Anne E.
dash.waiver2013-07-07
dc.date.available2015-05-18T20:36:40Z
dc.identifier.doi10.1073/pnas.1305049110*
dash.contributor.affiliatedAlim, Karen
dash.contributor.affiliatedBrenner, Michael
dash.contributor.affiliatedPringle, Anne E.


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