Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs

DSpace/Manakin Repository

Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs

Citable link to this page

 

 
Title: Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs
Author: Lai, Ka-Man Venus; Gong, Guochun; Atanasio, Amanda; Rojas, José; Quispe, Joseph; Posca, Julita; White, Derek; Huang, Mei; Fedorova, Daria; Grant, Craig; Miloscio, Lawrence; Droguett, Gustavo; Poueymirou, William T.; Auerbach, Wojtek; Yancopoulos, George D.; Frendewey, David; Rinn, John; Valenzuela, David M.

Note: Order does not necessarily reflect citation order of authors.

Citation: Lai, K. V., G. Gong, A. Atanasio, J. Rojas, J. Quispe, J. Posca, D. White, et al. 2015. “Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.” PLoS ONE 10 (4): e0125522. doi:10.1371/journal.pone.0125522. http://dx.doi.org/10.1371/journal.pone.0125522.
Full Text & Related Files:
Abstract: In a survey of 20 knockout mouse lines designed to examine the biological functions of large intergenic non-coding RNAs (lincRNAs), we have found a variety of phenotypes, ranging from perinatal lethality to defects associated with premature aging and morphological and functional abnormalities in the lungs, skeleton, and muscle. Each mutant allele carried a lacZ reporter whose expression profile highlighted a wide spectrum of spatiotemporal and tissue-specific transcription patterns in embryos and adults that informed our phenotypic analyses and will serve as a guide for future investigations of these genes. Our study shows that lincRNAs are a new class of encoded molecules that, like proteins, serve essential and important functional roles in embryonic development, physiology, and homeostasis of a broad array of tissues and organs in mammals.
Published Version: doi:10.1371/journal.pone.0125522
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409293/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:16120839
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters