Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype

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Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype

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Title: Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype
Author: Jalbut, Marla M.; Sohani, Aliyah R.; Cin, Paola Dal; Hasserjian, Robert P.; Moran, Jenna A.; Brunner, Andrew M.; Fathi, Amir T.

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Citation: Jalbut, Marla M., Aliyah R. Sohani, Paola Dal Cin, Robert P. Hasserjian, Jenna A. Moran, Andrew M. Brunner, and Amir T. Fathi. 2015. “Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype.” Leukemia Research Reports 4 (1): 28-30. doi:10.1016/j.lrr.2015.04.001. http://dx.doi.org/10.1016/j.lrr.2015.04.001.
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Abstract: Klinefelter syndrome (KS), a 47,XXY chromosomal abnormality, has been shown to be associated with a number of malignancies, but has not been linked to acute leukemias to date. We present a case of a 54-year-old male diagnosed with acute myeloid leukemia (AML) with monocytic differentiation, whose cytogenetic and subsequent FISH analyses revealed a constitutional 47,XXY karyotype. We also review and discuss relevant prior literature.
Published Version: doi:10.1016/j.lrr.2015.04.001
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421110/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:16120851
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