Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype
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Author
Jalbut, Marla M.
Sohani, Aliyah R.
Cin, Paola Dal
Moran, Jenna A.
Published Version
https://doi.org/10.1016/j.lrr.2015.04.001Metadata
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Jalbut, Marla M., Aliyah R. Sohani, Paola Dal Cin, Robert P. Hasserjian, Jenna A. Moran, Andrew M. Brunner, and Amir T. Fathi. 2015. “Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype.” Leukemia Research Reports 4 (1): 28-30. doi:10.1016/j.lrr.2015.04.001. http://dx.doi.org/10.1016/j.lrr.2015.04.001.Abstract
Klinefelter syndrome (KS), a 47,XXY chromosomal abnormality, has been shown to be associated with a number of malignancies, but has not been linked to acute leukemias to date. We present a case of a 54-year-old male diagnosed with acute myeloid leukemia (AML) with monocytic differentiation, whose cytogenetic and subsequent FISH analyses revealed a constitutional 47,XXY karyotype. We also review and discuss relevant prior literature.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421110/pdf/Terms of Use
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