Monoalkoxy BODIPYs—A Fluorophore Class for Bioimaging
| Title: | Monoalkoxy BODIPYs—A Fluorophore Class for Bioimaging |
| Author: |
Courtis, Alexandra
M.; Santos, Sofia A.; Guan, Yinghua; Hendricks, J. Adam; Ghosh, Balaram; Szantai-Kis, D. Miklos; Reis, Surya A.; Shah, Jagesh V.; Mazitschek, Ralph
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Courtis, Alexandra M., Sofia A. Santos, Yinghua Guan, J. Adam Hendricks, Balaram Ghosh, D. Miklos Szantai-Kis, Surya A. Reis, Jagesh V. Shah, and Ralph Mazitschek. 2014. “Monoalkoxy BODIPYs—A Fluorophore Class for Bioimaging.” Bioconjugate Chemistry 25 (6): 1043-1051. doi:10.1021/bc400575w. http://dx.doi.org/10.1021/bc400575w. |
| Full Text & Related Files: |
4215867.pdf (3.586Mb; PDF) 
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| Abstract: | Small molecule fluorophores are indispensable tools for modern biomedical imaging techniques. In this report, we present the development of a new class of BODIPY dyes based on an alkoxy-fluoro-boron-dipyrromethene core. These novel fluorescent dyes, which we term MayaFluors, are characterized by good aqueous solubility and favorable in vitro physicochemical properties. MayaFluors are readily accessible in good yields in a one-pot, two-step approach starting from well-established BODIPY dyes, and allow for facile modification with functional groups of relevance to bioconjugate chemistry and bioorthogonal labeling. Biological profiling in living cells demonstrates excellent membrane permeability, low nonspecific binding, and lack of cytotoxicity. |
| Published Version: | doi:10.1021/bc400575w |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215867/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:16120863 |
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