Monoalkoxy BODIPYs—A Fluorophore Class for Bioimaging

DSpace/Manakin Repository

Monoalkoxy BODIPYs—A Fluorophore Class for Bioimaging

Citable link to this page

 

 
Title: Monoalkoxy BODIPYs—A Fluorophore Class for Bioimaging
Author: Courtis, Alexandra M.; Santos, Sofia A.; Guan, Yinghua; Hendricks, J. Adam; Ghosh, Balaram; Szantai-Kis, D. Miklos; Reis, Surya A.; Shah, Jagesh V.; Mazitschek, Ralph

Note: Order does not necessarily reflect citation order of authors.

Citation: Courtis, Alexandra M., Sofia A. Santos, Yinghua Guan, J. Adam Hendricks, Balaram Ghosh, D. Miklos Szantai-Kis, Surya A. Reis, Jagesh V. Shah, and Ralph Mazitschek. 2014. “Monoalkoxy BODIPYs—A Fluorophore Class for Bioimaging.” Bioconjugate Chemistry 25 (6): 1043-1051. doi:10.1021/bc400575w. http://dx.doi.org/10.1021/bc400575w.
Full Text & Related Files:
Abstract: Small molecule fluorophores are indispensable tools for modern biomedical imaging techniques. In this report, we present the development of a new class of BODIPY dyes based on an alkoxy-fluoro-boron-dipyrromethene core. These novel fluorescent dyes, which we term MayaFluors, are characterized by good aqueous solubility and favorable in vitro physicochemical properties. MayaFluors are readily accessible in good yields in a one-pot, two-step approach starting from well-established BODIPY dyes, and allow for facile modification with functional groups of relevance to bioconjugate chemistry and bioorthogonal labeling. Biological profiling in living cells demonstrates excellent membrane permeability, low nonspecific binding, and lack of cytotoxicity.
Published Version: doi:10.1021/bc400575w
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215867/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:16120863
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters