Language and Traits of Autism Spectrum Conditions: Evidence of Limited Phenotypic and Etiological Overlap

DSpace/Manakin Repository

Language and Traits of Autism Spectrum Conditions: Evidence of Limited Phenotypic and Etiological Overlap

Citable link to this page

 

 
Title: Language and Traits of Autism Spectrum Conditions: Evidence of Limited Phenotypic and Etiological Overlap
Author: Taylor, Mark J.; Charman, Tony; Robinson, Elise B.; Hayiou-Thomas, Marianna E.; Happé, Francesca; Dale, Philip S.; Ronald, Angelica

Note: Order does not necessarily reflect citation order of authors.

Citation: Taylor, Mark J., Tony Charman, Elise B. Robinson, Marianna E. Hayiou-Thomas, Francesca Happé, Philip S. Dale, and Angelica Ronald. 2015. “Language and Traits of Autism Spectrum Conditions: Evidence of Limited Phenotypic and Etiological Overlap.” American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 0 (7): 587-595. doi:10.1002/ajmg.b.32262. http://dx.doi.org/10.1002/ajmg.b.32262.
Full Text & Related Files:
Abstract: Language difficulties have historically been viewed as integral to autism spectrum conditions (ASC), leading molecular genetic studies to consider whether ASC and language difficulties have overlapping genetic bases. The extent of genetic, and also environmental, overlap between ASC and language is, however, unclear. We hence conducted a twin study of the concurrent association between autistic traits and receptive language abilities. Internet-based language tests were completed by ~3,000 pairs of twins, while autistic traits were assessed via parent ratings. Twin model fitting explored the association between these measures in the full sample, while DeFries-Fulker analysis tested these associations at the extremes of the sample. Phenotypic associations between language ability and autistic traits were modest and negative. The degree of genetic overlap was also negative, indicating that genetic influences on autistic traits lowered language scores in the full sample (mean genetic correlation = −0.13). Genetic overlap was also low at the extremes of the sample (mean genetic correlation = 0.14), indicating that genetic influences on quantitatively defined language difficulties were largely distinct from those on extreme autistic traits. Variation in language ability and autistic traits were also associated with largely different nonshared environmental influences. Language and autistic traits are influenced by largely distinct etiological factors. This has implications for molecular genetic studies of ASC and understanding the etiology of ASC. Additionally, these findings lend support to forthcoming DSM-5 changes to ASC diagnostic criteria that will see language difficulties separated from the core ASC communication symptoms, and instead listed as a clinical specifier.
Published Version: doi:10.1002/ajmg.b.32262
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419741/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:16120894
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters