Glycolytic metabolism influences global chromatin structure

DSpace/Manakin Repository

Glycolytic metabolism influences global chromatin structure

Citable link to this page


Title: Glycolytic metabolism influences global chromatin structure
Author: Liu, Xue-Song; Little, John B.; Yuan, Zhi-Min

Note: Order does not necessarily reflect citation order of authors.

Citation: Liu, Xue-Song, John B. Little, and Zhi-Min Yuan. 2015. “Glycolytic metabolism influences global chromatin structure.” Oncotarget 6 (6): 4214-4225.
Full Text & Related Files:
Abstract: Metabolic rewiring, specifically elevated glycolytic metabolism is a hallmark of cancer. Global chromatin structure regulates gene expression, DNA repair, and also affects cancer progression. But the interrelationship between tumor metabolism and chromatin architecture remain unclear. Here we show that increased glycolysis in cancer cells promotes an open chromatin configuration. Using complementary methods including Micrococcal nuclease (MNase) digestion assay, electron microscope and immunofluorescence staining, we demonstrate that glycolysis inhibition by pharmacological and genetic approaches was associated with induction of compacted chromatin structure. This condensed chromatin status appeared to result chiefly from histone hypoacetylation as restoration of histone acetylation with an HDAC inhibitor reversed the compacted chromatin state. Interestingly, glycolysis inhibition-induced chromatin condensation impeded DNA repair efficiency leading to increased sensitivity of cancer cells to DNA damage drugs, which may represent a novel molecular mechanism that can be exploited for cancer therapy.
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search