Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells

DSpace/Manakin Repository

Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells

Citable link to this page

 

 
Title: Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells
Author: Tripathi, Sudipta; Chabtini, Lola; Dakle, Pranal J.; Smith, Brian; Akiba, Hisaya; Yagita, Hideo; Guleria, Indira

Note: Order does not necessarily reflect citation order of authors.

Citation: Tripathi, Sudipta, Lola Chabtini, Pranal J. Dakle, Brian Smith, Hisaya Akiba, Hideo Yagita, and Indira Guleria. 2015. “Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells.” PLoS ONE 10 (4): e0123439. doi:10.1371/journal.pone.0123439. http://dx.doi.org/10.1371/journal.pone.0123439.
Full Text & Related Files:
Abstract: NK cells are the most abundant lymphocyte population in the feto-maternal interface during gestation. The uterine NK cells (uNK) are transient, have a unique immunophenotype and produce a number of cytokines. These cytokines play an important role in establishment and maintenance of vascular remodeling and tolerance associated with successful pregnancy. The uNK cells also express TIM-3 during gestation and blockade of TIM-3 expression results in fetal loss in mice. In this study we determined the effect of TIM-3 blockade on uNK cells. Specifically we observed surface receptor phenotype and cytokine production by uNK cells following TIM-3 blockade. Our results show that TIM-3 plays a role in regulating the uNK cells and contributes to the maintenance of tolerance at the feto-maternal interface.
Published Version: doi:10.1371/journal.pone.0123439
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405344/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:16120957
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters