Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells
Dakle, Pranal J.
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CitationTripathi, Sudipta, Lola Chabtini, Pranal J. Dakle, Brian Smith, Hisaya Akiba, Hideo Yagita, and Indira Guleria. 2015. “Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells.” PLoS ONE 10 (4): e0123439. doi:10.1371/journal.pone.0123439. http://dx.doi.org/10.1371/journal.pone.0123439.
AbstractNK cells are the most abundant lymphocyte population in the feto-maternal interface during gestation. The uterine NK cells (uNK) are transient, have a unique immunophenotype and produce a number of cytokines. These cytokines play an important role in establishment and maintenance of vascular remodeling and tolerance associated with successful pregnancy. The uNK cells also express TIM-3 during gestation and blockade of TIM-3 expression results in fetal loss in mice. In this study we determined the effect of TIM-3 blockade on uNK cells. Specifically we observed surface receptor phenotype and cytokine production by uNK cells following TIM-3 blockade. Our results show that TIM-3 plays a role in regulating the uNK cells and contributes to the maintenance of tolerance at the feto-maternal interface.
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