Dual roles for hepatic lectin receptors in the clearance of chilled platelets
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Rumjantseva, Viktoria
Grewal, Prabhjit K.
Wandall, Hans H.
Josefsson, Emma C.
Sørensen, Anne Louise
Larson, Göran
Marth, Jamey D.
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https://doi.org/10.1038/nm.2030Metadata
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Rumjantseva, Viktoria, Prabhjit K. Grewal, Hans H. Wandall, Emma C. Josefsson, Anne Louise Sørensen, Göran Larson, Jamey D. Marth, John H. Hartwig, and Karin M. Hoffmeister. 2015. “Dual roles for hepatic lectin receptors in the clearance of chilled platelets.” Nature medicine 15 (11): 1273-1280. doi:10.1038/nm.2030. http://dx.doi.org/10.1038/nm.2030.Abstract
Chilling rapidly (<4 h) clusters Glycoprotein - (GP)Ib receptors on blood platelets, and ß2-integrins of hepatic macrophages bind ßGlcNAc residues in the clusters leading to rapid clearance of acutely chilled platelets following transfusion. Although capping the ßGlcNAc moieties by galactosylation prevents clearance, this strategy is ineffective after prolonged (>24 h) refrigeration. We report here that prolonged refrigeration increases the density/concentration of exposed galactose residues such that hepatocytes become increasingly involved in the removal of platelets using their Ashwell-Morell receptors. Macrophages always rapidly remove a large fraction of transfused platelets (~40%). With platelet cooling, hepatocyte-dependent clearance further diminishes their recoveries following transfusion.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428152/pdf/Terms of Use
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