Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine

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Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine

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Title: Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine
Author: He, YingYing; Liu, ShuBai; Leone, Serena; Newburg, David S.

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Citation: He, YingYing, ShuBai Liu, Serena Leone, and David S. Newburg. 2014. “Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine.” Mucosal immunology 7 (6): 1326-1339. doi:10.1038/mi.2014.20. http://dx.doi.org/10.1038/mi.2014.20.
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Abstract: The immature neonatal intestinal immune system hyperreacts to newly colonizing unfamiliar bacteria. The hypothesis that human milk oligosaccharides from colostrum (cHMOS) can directly modulate the signaling pathways of the immature mucosa was tested. Modulation of cytokine immune signaling by HMOS was measured ex vivo in intact immature (fetal) human intestinal mucosa. From the genes whose transcription was modulated by colostrum HMOS (cHMOS), Ingenuity Pathway Analysis identified networks controlling immune cell communication, intestinal mucosal immune system differentiation, and homeostasis. cHMOS attenuate pathogen-associated molecular pattern (PAMP)-stimulated acute phase inflammatory cytokine protein levels (IL-8, IL-6, MCP-1/2, IL-1β), while elevating cytokines involved in tissue repair and homeostasis. 3’-, 4-, and 6’-galactosyllactoses of cHMOS account for specific immunomodulation of PIC-induced IL-8 levels. cHMOS attenuate mucosal responses to surface inflammatory stimuli during early development, while enhancing signals that support maturation of the intestinal mucosal immune system.
Published Version: doi:10.1038/mi.2014.20
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183735/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:16121089
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