Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
DSpace/Manakin Repository
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
| Title: | Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks |
| Author: |
Malhotra, Deepali; Fletcher, Anne; Astarita, Jillian Leigh; Lukacs-Kornek, Veronika; Tayalia, Prakriti; Gonzalez, Santiago F.; Elpek, Kutlu G.; Chang, Sook Kyung; Knoblich, Konstantin; Hemler, Martin Edward; Brenner, Michael Barry; Carroll, Michael C.; Mooney, David J.; Turley, Shannon J.
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Malhotra, Deepali, Anne L Fletcher, Jillian Astarita, Veronika Lukacs-Kornek, Prakriti Tayalia, Santiago F Gonzalez, Kutlu G Elpek, et al. 2012. “Transcriptional Profiling of Stroma from Inflamed and Resting Lymph Nodes Defines Immunological Hallmarks.” Nature Immunology 13 (5) (April 1): 499–510. doi:10.1038/ni.2262. |
| Full Text & Related Files: |
3366863.pdf (4.883Mb; PDF) 
|
| Abstract: | Lymph node stromal cells (LNSCs) closely regulate immunity and self-tolerance, yet key aspects of their biology remain poorly illuminated. Comparative transcriptomic analyses of murine LNSC subsets revealed expression of important immune mediators, growth factors, and novel structural components. Pairwise analyses of ligands and cognate receptors across hematopoietic and stromal subsets suggested a complex web of cross-talk. Compared with skin and thymic fibroblasts, fibroblastic reticular cells (FRCs) were enriched in genes relevant to cytokine signaling. LNSCs from inflamed lymph nodes upregulated acute phase response genes, chemokines, and antigen presentation genes. Poorly studied podoplanin−CD31− LNSCs showed similarities to FRCs, but lacked IL-7 expression, and were identified as myofibroblastic integrin α7+ pericytes. Together these data comprehensively describe the transcriptional characteristics of LNSC subsets. |
| Published Version: | doi:10.1038/ni.2262 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366863/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:16235678 |
| Downloads of this work: |
This item appears in the following Collection(s)
-
HMS Scholarly Articles [20025]
-
FAS Scholarly Articles [15240]
Contact administrator regarding this item (to report mistakes or request changes)
