Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

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Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

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Title: Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
Author: Malhotra, Deepali; Fletcher, Anne; Astarita, Jillian Leigh; Lukacs-Kornek, Veronika; Tayalia, Prakriti; Gonzalez, Santiago F.; Elpek, Kutlu G.; Chang, Sook Kyung; Knoblich, Konstantin; Hemler, Martin Edward; Brenner, Michael Barry; Carroll, Michael C.; Mooney, David J.; Turley, Shannon J.

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Citation: Malhotra, Deepali, Anne L Fletcher, Jillian Astarita, Veronika Lukacs-Kornek, Prakriti Tayalia, Santiago F Gonzalez, Kutlu G Elpek, et al. 2012. “Transcriptional Profiling of Stroma from Inflamed and Resting Lymph Nodes Defines Immunological Hallmarks.” Nature Immunology 13 (5) (April 1): 499–510. doi:10.1038/ni.2262.
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Abstract: Lymph node stromal cells (LNSCs) closely regulate immunity and self-tolerance, yet key aspects of their biology remain poorly illuminated. Comparative transcriptomic analyses of murine LNSC subsets revealed expression of important immune mediators, growth factors, and novel structural components. Pairwise analyses of ligands and cognate receptors across hematopoietic and stromal subsets suggested a complex web of cross-talk. Compared with skin and thymic fibroblasts, fibroblastic reticular cells (FRCs) were enriched in genes relevant to cytokine signaling. LNSCs from inflamed lymph nodes upregulated acute phase response genes, chemokines, and antigen presentation genes. Poorly studied podoplanin−CD31− LNSCs showed similarities to FRCs, but lacked IL-7 expression, and were identified as myofibroblastic integrin α7+ pericytes. Together these data comprehensively describe the transcriptional characteristics of LNSC subsets.
Published Version: doi:10.1038/ni.2262
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366863/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:16235678
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