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dc.contributor.authorMalhotra, Deepali
dc.contributor.authorFletcher, Anne
dc.contributor.authorAstarita, Jillian Leigh
dc.contributor.authorLukacs-Kornek, Veronika
dc.contributor.authorTayalia, Prakriti
dc.contributor.authorGonzalez, Santiago F.
dc.contributor.authorElpek, Kutlu G.
dc.contributor.authorChang, Sook Kyung
dc.contributor.authorKnoblich, Konstantin
dc.contributor.authorHemler, Martin Edward
dc.contributor.authorBrenner, Michael Barry
dc.contributor.authorCarroll, Michael C.
dc.contributor.authorMooney, David J.
dc.contributor.authorTurley, Shannon J.
dc.date.accessioned2015-06-09T17:57:11Z
dc.date.issued2012
dc.identifier.citationMalhotra, Deepali, Anne L Fletcher, Jillian Astarita, Veronika Lukacs-Kornek, Prakriti Tayalia, Santiago F Gonzalez, Kutlu G Elpek, et al. 2012. “Transcriptional Profiling of Stroma from Inflamed and Resting Lymph Nodes Defines Immunological Hallmarks.” Nature Immunology 13 (5) (April 1): 499–510. doi:10.1038/ni.2262.en_US
dc.identifier.issn1529-2908en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:16235678
dc.description.abstractLymph node stromal cells (LNSCs) closely regulate immunity and self-tolerance, yet key aspects of their biology remain poorly illuminated. Comparative transcriptomic analyses of murine LNSC subsets revealed expression of important immune mediators, growth factors, and novel structural components. Pairwise analyses of ligands and cognate receptors across hematopoietic and stromal subsets suggested a complex web of cross-talk. Compared with skin and thymic fibroblasts, fibroblastic reticular cells (FRCs) were enriched in genes relevant to cytokine signaling. LNSCs from inflamed lymph nodes upregulated acute phase response genes, chemokines, and antigen presentation genes. Poorly studied podoplanin−CD31− LNSCs showed similarities to FRCs, but lacked IL-7 expression, and were identified as myofibroblastic integrin α7+ pericytes. Together these data comprehensively describe the transcriptional characteristics of LNSC subsets.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/ni.2262en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366863/pdf/en_US
dash.licenseOAP
dc.titleTranscriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarksen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNature Immunologyen_US
dash.depositing.authorMooney, David J.
dc.date.available2015-06-09T17:57:11Z
dc.identifier.doi10.1038/ni.2262*
workflow.legacycommentsNature publication but no waiver on file - so posted OAP.en_US
dash.authorsorderedfalse
dash.contributor.affiliatedAstarita, Jillian Leigh
dash.contributor.affiliatedMalhotra, Deepali
dash.contributor.affiliatedTayalia, Prakriti
dash.contributor.affiliatedHemler, Martin
dash.contributor.affiliatedChang, Sook Kyung
dash.contributor.affiliatedLukacs-Kornek, Veronika
dash.contributor.affiliatedFletcher, Anne Louise
dash.contributor.affiliatedTurley, Shannon J.
dash.contributor.affiliatedCarroll, Michael
dash.contributor.affiliatedMooney, David
dash.contributor.affiliatedBrenner, Michael


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