Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE
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Author
Ayton, Scott
Faux, Noel G.
Bush, Ashley I.
Weiner, Michael W.
Aisen, Paul
Petersen, Ronald
Jack Jr., Clifford R.
Jagust, William
Trojanowki, John Q.
Toga, Arthur W.
Beckett, Laurel
Saykin, Andrew J.
Morris, John
Shaw, Leslie M.
Khachaturian, Zaven
Sorensen, Greg
Kuller, Lew
Raichle, Marc
Paul, Steven
Davies, Peter
Fillit, Howard
Hefti, Franz
Holtzman, Davie
Marcel Mesulam, M.
Potter, William
Snyder, Peter
Schwartz, Adam
Montine, Tom
Thomas, Ronald G.
Donohue, Michael
Walter, Sarah
Gessert, Devon
Sather, Tamie
Jiminez, Gus
Harvey, Danielle
Bernstein, Matthew
Fox, Nick
Thompson, Paul
Schuff, Norbert
Borowski, Bret
Gunter, Jeff
Senjem, Matt
Vemuri, Prashanthi
Jones, David
Kantarci, Kejal
Ward, Chad
Koeppe, Robert A.
Foster, Norm
Reiman, Eric M.
Chen, Kewei
Mathis, Chet
Landau, Susan
Cairns, Nigel J.
Householder, Erin
Taylor-Reinwald, Lisa
Lee, Virginia
Korecka, Magdalena
Figurski, Michal
Crawford, Karen
Neu, Scott
Foroud, Tatiana M.
Potkin, Steven
Shen, Li
Faber, Kelley
Kim, Sungeun
Nho, Kwangsik
Thal, Leon
Buckholtz, Neil
Albert, Marylyn
Frank, Richard
Hsiao, John
Kaye, Jeffrey
Quinn, Joseph
Lind, Betty
Carter, Raina
Dolen, Sara
Schneider, Lon S.
Pawluczyk, Sonia
Beccera, Mauricio
Teodoro, Liberty
Spann, Bryan M.
Brewer, James
Vanderswag, Helen
Fleisher, Adam
Heidebrink, Judith L.
Lord, Joanne L.
Mason, Sara S.
Albers, Colleen S.
Knopman, David
Johnson, Kris
Doody, Rachelle S.
Villanueva-Meyer, Javier
Chowdhury, Munir
Rountree, Susan
Dang, Mimi
Stern, Yaakov
Honig, Lawrence S.
Bell, Karen L.
Ances, Beau
Carroll, Maria
Leon, Sue
Mintun, Mark A.
Schneider, Stacy
Oliver, Angela
Marson, Daniel
Griffith, Randall
Clark, David
Geldmacher, David
Brockington, John
Roberson, Erik
Grossman, Hillel
Mitsis, Effie
deToledo-Morrell, Leyla
Shah, Raj C.
Duara, Ranjan
Varon, Daniel
Greig, Maria T.
Roberts, Peggy
Albert, Marilyn
Onyike, Chiadi
D'Agostino II, Daniel
Kielb, Stephanie
Galvin, James E.
Cerbone, Brittany
Michel, Christina A.
Rusinek, Henry
de Leon, Mony J
Glodzik, Lidia
De Santi, Susan
Murali Doraiswamy, P.
Petrella, Jeffrey R.
Wong, Terence Z.
Arnold, Steven E.
Karlawish, Jason H.
Wolk, David
Smith, Charles D.
Jicha, Greg
Hardy, Peter
Sinha, Partha
Oates, Elizabeth
Conrad, Gary
Lopez, Oscar L.
Oakley, MaryAnn
Simpson, Donna M.
Porsteinsson, Anton P.
Goldstein, Bonnie S.
Martin, Kim
Makino, Kelly M.
Saleem Ismail, M.
Brand, Connie
Mulnard, Ruth A.
Thai, Gaby
Mc-Adams-Ortiz, Catherine
Womack, Kyle
Mathews, Dana
Quiceno, Mary
Diaz-Arrastia, Ramon
King, Richard
Weiner, Myron
Martin-Cook, Kristen
DeVous, Michael
Levey, Allan I.
Lah, James J.
Cellar, Janet S.
Burns, Jeffrey M.
Anderson, Heather S.
Swerdlow, Russell H.
Apostolova, Liana
Tingus, Kathleen
Woo, Ellen
Silverman, Daniel H.S.
Lu, Po H.
Bartzokis, George
Graff-Radford, Neill R
Parfitt, Francine
Kendall, Tracy
Johnson, Heather
Farlow, Martin R.
Hake, Ann Marie
Matthews, Brandy R.
Herring, Scott
Hunt, Cynthia
van Dyck, Christopher H.
Carson, Richard E.
MacAvoy, Martha G.
Chertkow, Howard
Bergman, Howard
Hosein, Chris
Black, Sandra
Stefanovic, Bojana
Caldwell, Curtis
Robin Hsiung, Ging-Yuek
Feldman, Howard
Mudge, Benita
Assaly, Michele
Kertesz, Andrew
Rogers, John
Bernick, Charles
Munic, Donna
Kerwin, Diana
Mesulam, Marek-Marsel
Lipowski, Kristine
Wu, Chuang-Kuo
Johnson, Nancy
Sadowsky, Carl
Martinez, Walter
Villena, Teresa
Scott Turner, Raymond
Johnson, Kathleen
Reynolds, Brigid
Frey, Meghan
Lane, Barton
Rosen, Allyson
Tinklenberg, Jared
Sabbagh, Marwan N.
Belden, Christine M.
Jacobson, Sandra A.
Sirrel, Sherye A.
Kowall, Neil
Killiany, Ronald
Budson, Andrew E.
Norbash, Alexander
Johnson, Patricia Lynn
Allard, Joanne
Lerner, Alan
Ogrocki, Paula
Hudson, Leon
Fletcher, Evan
Carmichael, Owen
Olichney, John
DeCarli, Charles
Kittur, Smita
Borrie, Michael
Lee, T-Y
Bartha, Rob
Johnson, Sterling
Asthana, Sanjay
Carlsson, Cynthia M.
Potkin, Steven G.
Preda, Adrian
Nguyen, Dana
Tariot, Pierre
Reeder, Stephanie
Bates, Vernice
Capote, Horacio
Rainka, Michelle
Scharre, Douglas W.
Kataki, Maria
Adeli, Anahita
Zimmerman, Earl A.
Celmins, Dzintra
Brown, Alice D.
Pearlson, Godfrey D.
Blank, Karen
Anderson, Karen
Santulli, Robert B.
Kitzmiller, Tamar J.
Schwartz, Eben S.
Sink, Kaycee M.
Williamson, Jeff D.
Garg, Pradeep
Watkins, Franklin
Ott, Brian R.
Querfurth, Henry
Tremont, Geoffrey
Salloway, Stephen
Malloy, Paul
Correia, Stephen
Rosen, Howard J.
Miller, Bruce L.
Mintzer, Jacobo
Spicer, Kenneth
Bachman, David
Finger, Elizabether
Pasternak, Stephen
Rachinsky, Irina
Drost, Dick
Pomara, Nunzio
Hernando, Raymundo
Sarrael, Antero
Schultz, Susan K.
Boles Ponto, Laura L.
Shim, Hyungsub
Elizabeth Smith, Karen
Relkin, Norman
Chaing, Gloria
Raudin, Lisa
Smith, Amanda
Fargher, Kristin
Ashok Raj, Balebail
Neylan, Thomas
Grafman, Jordan
Davis, Melissa
Morrison, Rosemary
Hayes, Jacqueline
Finley, Shannon
Friedl, Karl
Fleischman, Debra
Arfanakis, Konstantinos
James, Olga
Massoglia, Dino
Jay Fruehling, J.
Harding, Sandra
Peskind, Elaine R.
Petrie, Eric C.
Li, Gail
Yesavage, Jerome A.
Taylor, Joy L.
Furst, Ansgar J.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ncomms7760Metadata
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Ayton, S., N. G. Faux, A. I. Bush, M. W. Weiner, P. Aisen, R. Petersen, C. R. Jack Jr., et al. 2015. “Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE.” Nature Communications 6 (1): 6760. doi:10.1038/ncomms7760. http://dx.doi.org/10.1038/ncomms7760.Abstract
Brain iron elevation is implicated in Alzheimer's disease (AD) pathogenesis, but the impact of iron on disease outcomes has not been previously explored in a longitudinal study. Ferritin is the major iron storage protein of the body; by using cerebrospinal fluid (CSF) levels of ferritin as an index, we explored whether brain iron status impacts longitudinal outcomes in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. We show that baseline CSF ferritin levels were negatively associated with cognitive performance over 7 years in 91 cognitively normal, 144 mild cognitive impairment (MCI) and 67 AD subjects, and predicted MCI conversion to AD. Ferritin was strongly associated with CSF apolipoprotein E levels and was elevated by the Alzheimer's risk allele, APOE-ɛ4. These findings reveal that elevated brain iron adversely impacts on AD progression, and introduce brain iron elevation as a possible mechanism for APOE-ɛ4 being the major genetic risk factor for AD.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479012/pdf/Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:17295715
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