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dc.contributor.authorDrago, Joshuaen_US
dc.date.accessioned2015-07-13T19:43:57Z
dc.date.created2015-05en_US
dc.date.issued2015-06-08en_US
dc.date.submitted2015en_US
dc.identifier.citationDrago, Joshua. 2015. Buprenorphine Treatment for Opioid Addiction in the Primary Care Setting: Predictors of Treatment Success and Failure. Doctoral dissertation, Harvard Medical School.en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:17295887
dc.description.abstractBuprenorphine is a partial mu-opioid agonist with well-demonstrated efficacy in the medical treatment of opioid addiction. Little is known about which patients respond successfully to treatment with buprenorphine. To help answer this question, we performed a retrospective cohort analysis of 160 patients who received outpatient buprenorphine therapy for opioid addiction at MGH Charlestown HealthCare Center. We gathered information on 36 observable patient characteristics, and searched for variables which predict early failure, late failure or success at one year. We also created predictive logistic regression models based on these data. We found that while the overall rate of retention and sobriety at one year was 43.8%, a patient’s individual chances of success varied widely, ranging from 10%-80% depending on identifiable characteristics. Independent predictors of successful response to buprenorphine included increased age (p= .0013), female sex (p= .0200), employment (p = .0131), and having negative serological studies for hepatitis C (p = .0062). In secondary analyses, we found that younger age, male sex, and unemployment specifically predict early treatment failure. Finally, we found that high early percentage positive toxicology screens, injection drug use, and failure to participate in drug counseling specifically predict late treatment failure. We conclude that certain patient populations exhibit much higher risk of failing buprenorphine treatment than others, and may require special attention and/or support in order to provide them with equal chances of attaining sobriety.en_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoenen_US
dash.licenseLAAen_US
dc.titleBuprenorphine Treatment for Opioid Addiction in the Primary Care Setting: Predictors of Treatment Success and Failureen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorDrago, Joshuaen_US
dc.date.available2015-07-13T19:43:57Z
thesis.degree.date2015en_US
thesis.degree.grantorHarvard Medical Schoolen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Medicineen_US
dc.type.materialtexten_US
dash.identifier.vireohttp://etds.lib.harvard.edu/hms/admin/view/190en_US
dc.description.keywordsAddiction; Buprenorphine; Opioids; Predictors; Primary Careen_US
dash.author.emailjosh.drago@gmail.comen_US
dash.identifier.drsurn-3:HUL.DRS.OBJECT:25170927en_US
dash.identifier.orcid0000-0002-7245-1172en_US
dash.contributor.affiliatedDrago, Joshua
dc.identifier.orcid0000-0002-7245-1172


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