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dc.contributor.advisorHoekstra, Hopi E.en_US
dc.contributor.authorKingsley, Evan Prenticeen_US
dc.date.accessioned2015-07-17T16:52:17Z
dash.embargo.terms2015-11-01en_US
dc.date.created2015-05en_US
dc.date.issued2015-05-16en_US
dc.date.submitted2015en_US
dc.identifier.citationKingsley, Evan Prentice. 2015. Adaptation in the forest deer mouse: evolution, genetics, and development. Doctoral dissertation, Harvard University, Graduate School of Arts & Sciences.en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:17467192
dc.description.abstractVariation in the shape, size, and number of segments along the vertebral column underlies a vast amount of vertebrate diversity. Although the molecular pathways controlling vertebrate segmentation during normal development are well understood, the genetic and developmental underpinnings responsible for the tremendous variation in size and number of vertebrae are relatively unexplored. The main goal of this dissertation is to explore the genetic and developmental mechanisms influencing naturally occurring variation in the vertebral column. To this end, I focus on intraspecific skeletal variation, with an emphasis on tail length, in the deer mouse, Peromyscus maniculatus. In Chapter 1, I employ a phylogeographic framework to show that longer tails have evolved independently in different populations of forest-dwelling mice. Closer investigation of the underlying morphology shows that long-tailed mice have both (1) a greater number of tail vertebrae and (2) individually longer vertebrae, compared to ancestral short-tailed mice. Chapter 2 explores the genetic basis of tail length variation. I use quantitative trait locus mapping to uncover six loci that influence differences in total tail length (3 associated with vertebral length and 3 with vertebrae number). Finally, in Chapter 3 I combine comparative data from quantitative measurements of tissue dynamics during somitogenesis in fixed embryos and ex vivo explant culture to show that embryos of forest mice make more segments because they produce more presomitic mesoderm, and not because of any significant difference in the timing of somitogenesis. Together, this work integrates phylogeographic, genetic, and developmental studies to pinpoint the ways that natural selection modifies development to produce the repeated evolution of an evolutionarily important trait, and suggests that there are a limited number of ways that long tails can evolve.en_US
dc.description.sponsorshipBiology, Organismic and Evolutionaryen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoenen_US
dash.licenseLAAen_US
dc.subjectBiology, Geneticsen_US
dc.titleAdaptation in the forest deer mouse: evolution, genetics, and developmenten_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorKingsley, Evan Prenticeen_US
dc.date.available2015-11-02T08:30:43Z
thesis.degree.date2015en_US
thesis.degree.grantorGraduate School of Arts & Sciencesen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
dc.contributor.committeeMemberAbzhanov, Arkhaten_US
dc.contributor.committeeMemberHanken, Jamesen_US
dc.type.materialtexten_US
thesis.degree.departmentBiology, Organismic and Evolutionaryen_US
dash.identifier.vireohttp://etds.lib.harvard.edu/gsas/admin/view/383en_US
dc.description.keywordsphylogeography;genetics;development;embryology;Peromyscus;tail;vertebra;QTL;segmentationen_US
dash.author.emailkingsleyevan@gmail.comen_US
dash.identifier.drsurn-3:HUL.DRS.OBJECT:25164251en_US
dash.contributor.affiliatedKingsley, Evan


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