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dc.contributor.advisorMarti, Matthiasen_US
dc.contributor.advisorClardy, Jonen_US
dc.contributor.authorGoldowitz, Ilana Sarahen_US
dc.date.accessioned2015-07-17T17:40:01Z
dc.date.created2015-05en_US
dc.date.issued2015-05-13en_US
dc.date.submitted2015en_US
dc.identifier.citationGoldowitz, Ilana Sarah. 2015. Plasmodium's Crossroads: Deciphering the Molecular Pathway That Leads to Malaria Transmission. Doctoral dissertation, Harvard University, Graduate School of Arts & Sciences.en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:17467311
dc.description.abstractPlasmodium falciparum is the causative agent of the most severe form of malaria. Transmission from humans to mosquito vectors is an essential step in this eukaryotic parasite‘s life cycle and in the spread of malaria disease, which killed nearly 600,000 people in 2013. I investigated the developmental switch parasites make to the transmission stage or gametocyte, with the goal of identifying molecular mechanisms and environmental triggers of gametocyte formation. In Chapter 2 of this dissertation, I discuss the completion of a genetic mutagenesis screen leading to the discovery of a putative E3 ubiquitin ligase enzyme which is likely a negative regulator of gametocyte formation. Chapter 3 presents findings on population-based regulation of gametocyte production and on parasite-derived microvesicles that transfer between cells and stimulate gametocyte production. In Chapter 4, I and coauthors present a protocol for measuring parasite growth and gametocyte production in response to drugs or other treatments.en_US
dc.description.sponsorshipChemical Biologyen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoenen_US
dash.licenseLAAen_US
dc.subjectBiology, Parasitologyen_US
dc.subjectBiology, Microbiologyen_US
dc.subjectBiology, Molecularen_US
dc.titlePlasmodium's Crossroads: Deciphering the Molecular Pathway That Leads to Malaria Transmissionen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorGoldowitz, Ilana Sarahen_US
dc.date.available2015-07-17T17:40:01Z
thesis.degree.date2015en_US
thesis.degree.grantorGraduate School of Arts & Sciencesen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US
dc.contributor.committeeMemberWirth, Dyann F.en_US
dc.contributor.committeeMemberDvorin, Jeffrey D.en_US
dc.type.materialtexten_US
thesis.degree.departmentChemical Biologyen_US
dash.identifier.vireohttp://etds.lib.harvard.edu/gsas/admin/view/255en_US
dc.description.keywordsGametocyte; malaria transmission; ubiquitin ligase; microvesicleen_US
dash.author.emailpicea_spp@yahoo.comen_US
dash.identifier.drsurn-3:HUL.DRS.OBJECT:25164587en_US
dash.contributor.affiliatedGoldowitz, Ilana


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