Injectable, spontaneously assembling inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy
Lewin, Sarah A.
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CitationKim, Jaeyun, Weiwei Aileen Li, Youngjin Choi, Sarah A. Lewin, Catia S. Verbeke, Glenn Dranoff, and David J. Mooney. 2015. “Injectable, spontaneously assembling inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.” Nature biotechnology 33 (1): 64-72. doi:10.1038/nbt.3071. http://dx.doi.org/10.1038/nbt.3071.
AbstractMaterials implanted in the body to program host immune cells are a promising alternative to transplantation of ex vivo–manipulated cells to direct an immune response, but required a surgical procedure. Here we demonstrate that high-aspectratio, mesoporous silica rods (MSRs) injected with a needle spontaneously assemble in vivo to form macroporous structures that provide a 3D cellular microenvironment for host immune cells. In mice, substantial numbers of DCs are recruited to the pores between the scaffold rods. The recruitment of DCs and their subsequent homing to lymph nodes can be modulated by sustained release of inflammatory signals and adjuvants from the scaffold. Moreover, injection of an MSR-based vaccine formulation enhances systemic TH1 and TH2 serum antibody and cytotoxic T cell levels compared to bolus controls. These findings suggest that injectable MSRs may serve as a multifunctional vaccine platform to modulate host immune cell function and provoke adaptive immune responses.
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