The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture

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The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture

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Title: The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture
Author: Astarita, Jillian L.; Cremasco, Viviana; Fu, Jianxin; Darnell, Max C.; Peck, James R.; Nieves-Bonilla, Janice M.; Song, Kai; Woodruff, Matthew C.; Gogineni, Alvin; Onder, Lucas; Ludewig, Burkhard; Weimer, Robby M.; Carroll, Michael C.; Mooney, David J.; Xia, Lijun; Turley, Shannon J.

Note: Order does not necessarily reflect citation order of authors.

Citation: Astarita, J. L., V. Cremasco, J. Fu, M. C. Darnell, J. R. Peck, J. M. Nieves-Bonilla, K. Song, et al. 2014. “The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture.” Nature immunology 16 (1): 75-84. doi:10.1038/ni.3035. http://dx.doi.org/10.1038/ni.3035.
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Abstract: In lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of FRCs is their propensity to contract collagen, yet this function is poorly understood. Here, we demonstrate that podoplanin (PDPN) regulated actomyosin contractility in FRCs. Under resting conditions, when FRCs are unlikely to encounter mature DCs expressing the PDPN receptor, CLEC-2, PDPN endowed FRCs with contractile function and exerted tension within the reticulum. Upon inflammation, CLEC-2 on mature DCs potently attenuated PDPN-mediated contractility, resulting in FRC relaxation and reduced tissue stiffness. Disrupting PDPN function altered the homeostasis and spacing of FRCs and T cells, resulting in an expanded reticular network and enhanced immunity.
Published Version: doi:10.1038/ni.3035
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270928/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:17820645
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