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dc.contributor.authorAstarita, Jillian L.en_US
dc.contributor.authorCremasco, Vivianaen_US
dc.contributor.authorFu, Jianxinen_US
dc.contributor.authorDarnell, Max C.en_US
dc.contributor.authorPeck, James R.en_US
dc.contributor.authorNieves-Bonilla, Janice M.en_US
dc.contributor.authorSong, Kaien_US
dc.contributor.authorWoodruff, Matthew C.en_US
dc.contributor.authorGogineni, Alvinen_US
dc.contributor.authorOnder, Lucasen_US
dc.contributor.authorLudewig, Burkharden_US
dc.contributor.authorWeimer, Robby M.en_US
dc.contributor.authorCarroll, Michael C.en_US
dc.contributor.authorMooney, David J.en_US
dc.contributor.authorXia, Lijunen_US
dc.contributor.authorTurley, Shannon J.en_US
dc.date.accessioned2015-08-03T13:58:59Z
dc.date.issued2014en_US
dc.identifier.citationAstarita, J. L., V. Cremasco, J. Fu, M. C. Darnell, J. R. Peck, J. M. Nieves-Bonilla, K. Song, et al. 2014. “The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture.” Nature immunology 16 (1): 75-84. doi:10.1038/ni.3035. http://dx.doi.org/10.1038/ni.3035.en
dc.identifier.issn1529-2908en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:17820645
dc.description.abstractIn lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of FRCs is their propensity to contract collagen, yet this function is poorly understood. Here, we demonstrate that podoplanin (PDPN) regulated actomyosin contractility in FRCs. Under resting conditions, when FRCs are unlikely to encounter mature DCs expressing the PDPN receptor, CLEC-2, PDPN endowed FRCs with contractile function and exerted tension within the reticulum. Upon inflammation, CLEC-2 on mature DCs potently attenuated PDPN-mediated contractility, resulting in FRC relaxation and reduced tissue stiffness. Disrupting PDPN function altered the homeostasis and spacing of FRCs and T cells, resulting in an expanded reticular network and enhanced immunity.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ni.3035en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270928/pdf/en
dash.licenseLAAen_US
dc.titleThe CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitectureen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature immunologyen
dash.depositing.authorDarnell, Max C.en_US
dc.date.available2015-08-03T13:58:59Z
dc.identifier.doi10.1038/ni.3035*
dash.authorsorderedfalse
dash.contributor.affiliatedDarnell, Max
dash.contributor.affiliatedTurley, Shannon J.
dash.contributor.affiliatedCarroll, Michael
dash.contributor.affiliatedMooney, David


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