dc.contributor.author | Nettleton, Jennifer A. | en_US |
dc.contributor.author | Follis, Jack L. | en_US |
dc.contributor.author | Ngwa, Julius S. | en_US |
dc.contributor.author | Smith, Caren E. | en_US |
dc.contributor.author | Ahmad, Shafqat | en_US |
dc.contributor.author | Tanaka, Toshiko | en_US |
dc.contributor.author | Wojczynski, Mary K. | en_US |
dc.contributor.author | Voortman, Trudy | en_US |
dc.contributor.author | Lemaitre, Rozenn N. | en_US |
dc.contributor.author | Kristiansson, Kati | en_US |
dc.contributor.author | Nuotio, Marja-Liisa | en_US |
dc.contributor.author | Houston, Denise K. | en_US |
dc.contributor.author | Perälä, Mia-Maria | en_US |
dc.contributor.author | Qi, Qibin | en_US |
dc.contributor.author | Sonestedt, Emily | en_US |
dc.contributor.author | Manichaikul, Ani | en_US |
dc.contributor.author | Kanoni, Stavroula | en_US |
dc.contributor.author | Ganna, Andrea | en_US |
dc.contributor.author | Mikkilä, Vera | en_US |
dc.contributor.author | North, Kari E. | en_US |
dc.contributor.author | Siscovick, David S. | en_US |
dc.contributor.author | Harald, Kennet | en_US |
dc.contributor.author | Mckeown, Nicola M. | en_US |
dc.contributor.author | Johansson, Ingegerd | en_US |
dc.contributor.author | Rissanen, Harri | en_US |
dc.contributor.author | Liu, Yongmei | en_US |
dc.contributor.author | Lahti, Jari | en_US |
dc.contributor.author | Hu, Frank B. | en_US |
dc.contributor.author | Bandinelli, Stefania | en_US |
dc.contributor.author | Rukh, Gull | en_US |
dc.contributor.author | Rich, Stephen | en_US |
dc.contributor.author | Booij, Lisanne | en_US |
dc.contributor.author | Dmitriou, Maria | en_US |
dc.contributor.author | Ax, Erika | en_US |
dc.contributor.author | Raitakari, Olli | en_US |
dc.contributor.author | Mukamal, Kenneth | en_US |
dc.contributor.author | Männistö, Satu | en_US |
dc.contributor.author | Hallmans, Göran | en_US |
dc.contributor.author | Jula, Antti | en_US |
dc.contributor.author | Ericson, Ulrika | en_US |
dc.contributor.author | Jacobs,, David R. | en_US |
dc.contributor.author | Van Rooij, Frank J. A. | en_US |
dc.contributor.author | Deloukas, Panos | en_US |
dc.contributor.author | Sjögren, Per | en_US |
dc.contributor.author | Kähönen, Mika | en_US |
dc.contributor.author | Djousse, Luc | en_US |
dc.contributor.author | Perola, Markus | en_US |
dc.contributor.author | Barroso, Inês | en_US |
dc.contributor.author | Hofman, Albert | en_US |
dc.contributor.author | Stirrups, Kathleen | en_US |
dc.contributor.author | Viikari, Jorma | en_US |
dc.contributor.author | Uitterlinden, André G. | en_US |
dc.contributor.author | Kalafati, Ioanna P. | en_US |
dc.contributor.author | Franco, Oscar H. | en_US |
dc.contributor.author | Mozaffarian, Dariush | en_US |
dc.contributor.author | Salomaa, Veikko | en_US |
dc.contributor.author | Borecki, Ingrid B. | en_US |
dc.contributor.author | Knekt, Paul | en_US |
dc.contributor.author | Kritchevsky, Stephen B. | en_US |
dc.contributor.author | Eriksson, Johan G. | en_US |
dc.contributor.author | Dedoussis, George V. | en_US |
dc.contributor.author | Qi, Lu | en_US |
dc.contributor.author | Ferrucci, Luigi | en_US |
dc.contributor.author | Orho-Melander, Marju | en_US |
dc.contributor.author | Zillikens, M. Carola | en_US |
dc.contributor.author | Ingelsson, Erik | en_US |
dc.contributor.author | Lehtimäki, Terho | en_US |
dc.contributor.author | Renström, Frida | en_US |
dc.contributor.author | Cupples, L. Adrienne | en_US |
dc.contributor.author | Loos, Ruth J. F. | en_US |
dc.contributor.author | Franks, Paul W. | en_US |
dc.date.accessioned | 2015-08-03T13:59:27Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Nettleton, J. A., J. L. Follis, J. S. Ngwa, C. E. Smith, S. Ahmad, T. Tanaka, M. K. Wojczynski, et al. 2015. “Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry.” Human Molecular Genetics 24 (16): 4728-4738. doi:10.1093/hmg/ddv186. http://dx.doi.org/10.1093/hmg/ddv186. | en |
dc.identifier.issn | 0964-6906 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:17820670 | |
dc.description.abstract | Obesity is highly heritable. Genetic variants showing robust associations with obesity traits have been identified through genome-wide association studies. We investigated whether a composite score representing healthy diet modifies associations of these variants with obesity traits. Totally, 32 body mass index (BMI)- and 14 waist–hip ratio (WHR)-associated single nucleotide polymorphisms were genotyped, and genetic risk scores (GRS) were calculated in 18 cohorts of European ancestry (n = 68 317). Diet score was calculated based on self-reported intakes of whole grains, fish, fruits, vegetables, nuts/seeds (favorable) and red/processed meats, sweets, sugar-sweetened beverages and fried potatoes (unfavorable). Multivariable adjusted, linear regression within each cohort followed by inverse variance-weighted, fixed-effects meta-analysis was used to characterize: (a) associations of each GRS with BMI and BMI-adjusted WHR and (b) diet score modification of genetic associations with BMI and BMI-adjusted WHR. Nominally significant interactions (P = 0.006–0.04) were observed between the diet score and WHR-GRS (but not BMI-GRS), two WHR loci (GRB14 rs10195252; LYPLAL1 rs4846567) and two BMI loci (LRRN6C rs10968576; MTIF3 rs4771122), for the respective BMI-adjusted WHR or BMI outcomes. Although the magnitudes of these select interactions were small, our data indicated that associations between genetic predisposition and obesity traits were stronger with a healthier diet. Our findings generate interesting hypotheses; however, experimental and functional studies are needed to determine their clinical relevance. | en |
dc.language.iso | en_US | en |
dc.publisher | Oxford University Press | en |
dc.relation.isversionof | doi:10.1093/hmg/ddv186 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512626/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Human Molecular Genetics | en |
dash.depositing.author | Hu, Frank B. | en_US |
dc.date.available | 2015-08-03T13:59:27Z | |
dc.identifier.doi | 10.1093/hmg/ddv186 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Djousse, Luc | |
dash.contributor.affiliated | Mukamal, Kenneth | |
dash.contributor.affiliated | Hu, Frank | |
dash.contributor.affiliated | Qi, Lu | |
dash.contributor.affiliated | Franks, Paul | |