Show simple item record

dc.contributor.authorChung, Hyun Jungen_US
dc.contributor.authorPellegrini, Kathryn L.en_US
dc.contributor.authorChung, Jaehoonen_US
dc.contributor.authorWanigasuriya, Kamanien_US
dc.contributor.authorJayawardene, Innocenten_US
dc.contributor.authorLee, Kyungheonen_US
dc.contributor.authorLee, Hakhoen_US
dc.contributor.authorVaidya, Vishal S.en_US
dc.contributor.authorWeissleder, Ralphen_US
dc.date.accessioned2015-08-03T13:59:36Z
dc.date.issued2015en_US
dc.identifier.citationChung, Hyun Jung, Kathryn L. Pellegrini, Jaehoon Chung, Kamani Wanigasuriya, Innocent Jayawardene, Kyungheon Lee, Hakho Lee, Vishal S. Vaidya, and Ralph Weissleder. 2015. “Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury.” PLoS ONE 10 (7): e0133417. doi:10.1371/journal.pone.0133417. http://dx.doi.org/10.1371/journal.pone.0133417.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:17820689
dc.description.abstractThe high incidence of acute and chronic kidney injury due to various environmental factors such as heavy metals or chemicals has been a major problem in developing countries. However, the diagnosis of kidney injury in these areas can be more challenging due to the lack of highly sensitive and specific techniques that can be applied in point-of-care settings. To address this, we have developed a technique called ‘micro-urine nanoparticle detection (μUNPD)’, that allows the detection of trace amounts of molecular markers in urine. Specifically, this technique utilizes an automated on-chip assay followed by detection with a hand-held device for the read-out. Using the μUNPD technology, the kidney injury markers KIM-1 and Cystatin C were detected down to concentrations of 0.1 ng/ml and 20 ng/ml respectively, which meets the cut-off range required to identify patients with acute or chronic kidney injury. Thus, we show that the μUNPD technology enables point of care and non-invasive detection of kidney injury, and has potential for applications in diagnosing kidney injury with high sensitivity in resource-limited settings.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0133417en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506142/pdf/en
dash.licenseLAAen_US
dc.titleNanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injuryen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorLee, Kyungheonen_US
dc.date.available2015-08-03T13:59:36Z
dc.identifier.doi10.1371/journal.pone.0133417*
dash.authorsorderedfalse
dash.contributor.affiliatedLee, Kyungheon
dash.contributor.affiliatedVaidya, Vishal
dash.contributor.affiliatedLee, Hakho
dash.contributor.affiliatedWeissleder, Ralph


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record