Show simple item record

dc.contributor.authorAndreotti, Gabriellaen_US
dc.contributor.authorHoppin, Jane A.en_US
dc.contributor.authorHou, Lifangen_US
dc.contributor.authorKoutros, Stellaen_US
dc.contributor.authorGadalla, Shahinaz M.en_US
dc.contributor.authorSavage, Sharon A.en_US
dc.contributor.authorLubin, Jayen_US
dc.contributor.authorBlair, Aaronen_US
dc.contributor.authorHoxha, Mirjamen_US
dc.contributor.authorBaccarelli, Andreaen_US
dc.contributor.authorSandler, Daleen_US
dc.contributor.authorAlavanja, Michaelen_US
dc.contributor.authorBeane Freeman, Laura E.en_US
dc.date.accessioned2015-08-03T13:59:53Z
dc.date.issued2015en_US
dc.identifier.citationAndreotti, G., J. A. Hoppin, L. Hou, S. Koutros, S. M. Gadalla, S. A. Savage, J. Lubin, et al. 2015. “Pesticide Use and Relative Leukocyte Telomere Length in the Agricultural Health Study.” PLoS ONE 10 (7): e0133382. doi:10.1371/journal.pone.0133382. http://dx.doi.org/10.1371/journal.pone.0133382.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:17820702
dc.description.abstractSome studies suggest that telomere length (TL) may be influenced by environmental exposures, including pesticides. We examined associations between occupational pesticide use reported at three time points and relative telomere length (RTL) in the Agricultural Health Study (AHS), a prospective cohort study of pesticide applicators in Iowa and North Carolina. RTL was measured by qPCR using leukocyte DNA from 568 cancer-free male AHS participants aged 31-94 years with blood samples collected between 2006 and 2008. Self-reported information, including pesticide use, was collected at three time points: enrollment (1993-1997) and two follow-up questionnaires (1998-2003, 2005-2008). For each pesticide, we evaluated cumulative use (using data from all three questionnaires), and more recent use (using data from the last follow-up questionnaire). Multivariable linear regression was used to examine the associations between pesticide use (ever, lifetime days, intensity-weighted lifetime days (lifetime days*intensity score)) and RTL, adjusting for age at blood draw and use of other pesticides. Of the 57 pesticides evaluated with cumulative use, increasing lifetime days of 2,4-D (p-trend=0.001), diazinon (p-trend=0.002), and butylate (p-trend=0.01) were significantly associated with shorter RTL, while increasing lifetime days of alachlor was significantly associated with longer RTL (p-trend=0.03). Only the association with 2,4-D was significant after adjustment for multiple comparisons. Of the 40 pesticides evaluated for recent use, malathion was associated with shorter RTL (p=0.03), and alachlor with longer RTL (p=0.03). Our findings suggest that leukocyte TL may be impacted by cumulative use and recent use of certain pesticides.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0133382en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510132/pdf/en
dash.licenseLAAen_US
dc.titlePesticide Use and Relative Leukocyte Telomere Length in the Agricultural Health Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorBaccarelli, Andreaen_US
dc.date.available2015-08-03T13:59:53Z
dc.identifier.doi10.1371/journal.pone.0133382*
dash.authorsorderedfalse
dash.contributor.affiliatedBaccarelli, Andrea
dc.identifier.orcid0000-0002-3436-0640


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record