Adipose tissue n-3 fatty acids and metabolic syndrome

DSpace/Manakin Repository

Adipose tissue n-3 fatty acids and metabolic syndrome

Citable link to this page

 

 
Title: Adipose tissue n-3 fatty acids and metabolic syndrome
Author: Cespedes, Elizabeth; Baylin, Ana; Campos, Hannia

Note: Order does not necessarily reflect citation order of authors.

Citation: Cespedes, Elizabeth, Ana Baylin, and Hannia Campos. 2014. “Adipose tissue n-3 fatty acids and metabolic syndrome.” European journal of clinical nutrition 69 (1): 114-120. doi:10.1038/ejcn.2014.150. http://dx.doi.org/10.1038/ejcn.2014.150.
Full Text & Related Files:
Abstract: Background: Evidence regarding the relationship of n-3 fatty acids (FA) to type 2 diabetes (T2D) and metabolic syndrome components (MetS) is inconsistent. Objective: To examine associations of adipose tissue n-3 FA with MetS. Design: We studied 1611 participants without prior history of diabetes or heart disease who were participants in a population-based case-control study of diet and heart disease (The Costa Rica Heart Study). We calculated prevalence ratios (PR) and 95% confidence intervals (CI) for MetS by quartile of n-3 FA in adipose tissue derived mainly from plants [α-Linolenic acid (ALA)], fish [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], or metabolism [docosapentaenoic acid (DPA), as well as the EPA:ALA ratio, a surrogate marker of delta-6 desaturase activity]. Results: N-3 FA levels in adipose tissue were associated with MetS prevalence in opposite directions. The PR (95% CI) for the highest compared to the lowest quartile adjusted for age, sex, BMI, residence, lifestyle, diet and other fatty acids were 0.60 (0.44, 0.81) for ALA, 1.43 (1.12, 1.82) for EPA, 1.63 (1.22, 2.18) for DPA, and 1.47 (1.14, 1.88) for EPA:ALA, all p for trend <0.05. Although these associations were no longer significant (except DPA) after adjustment for BMI, ALA and DPA were associated with lower glucose and higher triglyceride levels, p<0.05 (respectively). Conclusions: These results suggest that ALA could exert a modest protective benefit, while EPA and DHA are not implicated in MetS. The positive associations for DPA and MetS could reflect higher delta-6 desaturase activity caused by increased adiposity.
Published Version: doi:10.1038/ejcn.2014.150
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286455/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:17820719
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters