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dc.contributor.authorHo, Po-Yien_US
dc.contributor.authorAmir, Arielen_US
dc.date.accessioned2015-08-03T14:00:23Z
dc.date.issued2015en_US
dc.identifier.citationHo, Po-Yi, and Ariel Amir. 2015. “Simultaneous regulation of cell size and chromosome replication in bacteria.” Frontiers in Microbiology 6 (1): 662. doi:10.3389/fmicb.2015.00662. http://dx.doi.org/10.3389/fmicb.2015.00662.en
dc.identifier.issn1664-302Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:17820738
dc.description.abstractBacteria are able to maintain a narrow distribution of cell sizes by regulating the timing of cell divisions. In rich nutrient conditions, cells divide much faster than their chromosomes replicate. This implies that cells maintain multiple rounds of chromosome replication per cell division by regulating the timing of chromosome replications. Here, we show that both cell size and chromosome replication may be simultaneously regulated by the long-standing initiator accumulation strategy. The strategy proposes that initiators are produced in proportion to the volume increase and is accumulated at each origin of replication, and chromosome replication is initiated when a critical amount per origin has accumulated. We show that this model maps to the incremental model of size control, which was previously shown to reproduce experimentally observed correlations between various events in the cell cycle and explains the exponential dependence of cell size on the growth rate of the cell. Furthermore, we show that this model also leads to the efficient regulation of the timing of initiation and the number of origins consistent with existing experimental results.en
dc.language.isoen_USen
dc.publisherFrontiers Media S.A.en
dc.relation.isversionofdoi:10.3389/fmicb.2015.00662en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498127/pdf/en
dash.licenseLAAen_US
dc.subjectreplication initiationen
dc.subjectcell cycleen
dc.subjectcell size regulationen
dc.subjectmultiple forksen
dc.subjectmathematical modelingen
dc.titleSimultaneous regulation of cell size and chromosome replication in bacteriaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalFrontiers in Microbiologyen
dash.depositing.authorHo, Po-Yien_US
dc.date.available2015-08-03T14:00:23Z
dc.identifier.doi10.3389/fmicb.2015.00662*
dash.contributor.affiliatedAmir, Ariel
dash.contributor.affiliatedHo, Po-Yi


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