dc.contributor.author | Kang, Sona | en_US |
dc.contributor.author | Tsai, Linus T. | en_US |
dc.contributor.author | Zhou, Yiming | en_US |
dc.contributor.author | Evertts, Adam | en_US |
dc.contributor.author | Xu, Su | en_US |
dc.contributor.author | Griffin, Michael J. | en_US |
dc.contributor.author | Issner, Robbyn | en_US |
dc.contributor.author | Whitton, Holly J. | en_US |
dc.contributor.author | Garcia, Benjamin A. | en_US |
dc.contributor.author | Epstein, Charles B. | en_US |
dc.contributor.author | Mikkelsen, Tarjei S. | en_US |
dc.contributor.author | Rosen, Evan D. | en_US |
dc.date.accessioned | 2015-08-03T14:01:59Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Kang, S., L. T. Tsai, Y. Zhou, A. Evertts, S. Xu, M. J. Griffin, R. Issner, et al. 2014. “Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.” Nature cell biology 17 (1): 44-56. doi:10.1038/ncb3080. http://dx.doi.org/10.1038/ncb3080. | en |
dc.identifier.issn | 1465-7392 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:17820822 | |
dc.description.abstract | Summary Insulin resistance is a sine qua non of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, aging, and steroid use, among others. How such a panoply of insults can result in a common phenotype is incompletely understood. Furthermore, very little is known about the transcriptional and epigenetic basis of this disorder, despite evidence that such pathways are likely to play a fundamental role. Here, we compare cell autonomous models of insulin resistance induced by the cytokine tumor necrosis factor-α (TNF) or by the steroid dexamethasone (Dex) to construct detailed transcriptional and epigenomic maps associated with cellular insulin resistance. These data predict that the glucocorticoid receptor and vitamin D receptor are common mediators of insulin resistance, which we validate using gain- and loss-of-function studies. These studies define a common transcriptional and epigenomic signature in cellular insulin resistance enabling the identification of pathogenic mechanisms. | en |
dc.language.iso | en_US | en |
dc.relation.isversionof | doi:10.1038/ncb3080 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281178/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature cell biology | en |
dash.depositing.author | Kang, Sona | en_US |
dc.date.available | 2015-08-03T14:01:59Z | |
dc.identifier.doi | 10.1038/ncb3080 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Tsai, Linus | |
dash.contributor.affiliated | Kang, Sona | |
dash.contributor.affiliated | Rosen, Evan | |