The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus
Hanna, Richard N.
Hedrick, Catherine C.Note: Order does not necessarily reflect citation order of authors.
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CitationTacke, R., I. Hilgendorf, H. Garner, C. Waterborg, K. Park, H. Nowyhed, R. N. Hanna, et al. 2015. “The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus.” Scientific Reports 5 (1): 10055. doi:10.1038/srep10055. http://dx.doi.org/10.1038/srep10055.
AbstractTissue macrophages function to maintain homeostasis and regulate immune responses. While tissue macrophages derive from one of a small number of progenitor programs, the transcriptional requirements for site-specific macrophage subset development are more complex. We have identified a new tissue macrophage subset in the thymus and have discovered that its development is dependent on transcription factor NR4A1. Functionally, we find that NR4A1-dependent macrophages are critically important for clearance of apoptotic thymocytes. These macrophages are largely reduced or absent in mice lacking NR4A1, and Nr4a1-deficient mice have impaired thymocyte engulfment and clearance. Thus, NR4A1 functions as a master transcription factor for the development of this novel thymus-specific macrophage subset.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:17820866
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