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dc.contributor.authorTacke, Roberten_US
dc.contributor.authorHilgendorf, Ingoen_US
dc.contributor.authorGarner, Hannahen_US
dc.contributor.authorWaterborg, Claireen_US
dc.contributor.authorPark, Kiwonen_US
dc.contributor.authorNowyhed, Hebaen_US
dc.contributor.authorHanna, Richard N.en_US
dc.contributor.authorWu, Runpeien_US
dc.contributor.authorSwirski, Filip K.en_US
dc.contributor.authorGeissmann, Fredericen_US
dc.contributor.authorHedrick, Catherine C.en_US
dc.date.accessioned2015-08-03T14:02:18Z
dc.date.issued2015en_US
dc.identifier.citationTacke, R., I. Hilgendorf, H. Garner, C. Waterborg, K. Park, H. Nowyhed, R. N. Hanna, et al. 2015. “The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus.” Scientific Reports 5 (1): 10055. doi:10.1038/srep10055. http://dx.doi.org/10.1038/srep10055.en
dc.identifier.issn2045-2322en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:17820866
dc.description.abstractTissue macrophages function to maintain homeostasis and regulate immune responses. While tissue macrophages derive from one of a small number of progenitor programs, the transcriptional requirements for site-specific macrophage subset development are more complex. We have identified a new tissue macrophage subset in the thymus and have discovered that its development is dependent on transcription factor NR4A1. Functionally, we find that NR4A1-dependent macrophages are critically important for clearance of apoptotic thymocytes. These macrophages are largely reduced or absent in mice lacking NR4A1, and Nr4a1-deficient mice have impaired thymocyte engulfment and clearance. Thus, NR4A1 functions as a master transcription factor for the development of this novel thymus-specific macrophage subset.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/srep10055en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473761/pdf/en
dash.licenseLAAen_US
dc.titleThe transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymusen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalScientific Reportsen
dash.depositing.authorSwirski, Filip K.en_US
dc.date.available2015-08-03T14:02:18Z
dc.identifier.doi10.1038/srep10055*
dash.authorsorderedfalse
dash.contributor.affiliatedSwirski, Filip


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