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dc.contributor.authorYuan, Aidongen_US
dc.contributor.authorHassinger, Lindaen_US
dc.contributor.authorRao, Mala V.en_US
dc.contributor.authorJulien, Jean-Pierreen_US
dc.contributor.authorMiller, Christopher C. J.en_US
dc.contributor.authorNixon, Ralph A.en_US
dc.date.accessioned2015-08-03T14:02:20Z
dc.date.issued2015en_US
dc.identifier.citationYuan, Aidong, Linda Hassinger, Mala V. Rao, Jean-Pierre Julien, Christopher C. J. Miller, and Ralph A. Nixon. 2015. “Dissociation of Axonal Neurofilament Content from Its Transport Rate.” PLoS ONE 10 (7): e0133848. doi:10.1371/journal.pone.0133848. http://dx.doi.org/10.1371/journal.pone.0133848.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:17820873
dc.description.abstractThe axonal cytoskeleton of neurofilament (NF) is a long-lived network of fibrous elements believed to be a stationary structure maintained by a small pool of transported cytoskeletal precursors. Accordingly, it may be predicted that NF content in axons can vary independently from the transport rate of NF. In the present report, we confirm this prediction by showing that human NFH transgenic mice and transgenic mice expressing human NFL Ser55 (Asp) develop nearly identical abnormal patterns of NF accumulation and distribution in association with opposite changes in NF slow transport rates. We also show that the rate of NF transport in wild-type mice remains constant along a length of the optic axon where NF content varies 3-fold. Moreover, knockout mice lacking NFH develop even more extreme (6-fold) proximal to distal variation in NF number, which is associated with a normal wild-type rate of NF transport. The independence of regional NF content and NF transport is consistent with previous evidence suggesting that the rate of incorporation of transported NF precursors into a metabolically stable stationary cytoskeletal network is the major determinant of axonal NF content, enabling the generation of the striking local variations in NF number seen along axons.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0133848en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514674/pdf/en
dash.licenseLAAen_US
dc.titleDissociation of Axonal Neurofilament Content from Its Transport Rateen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dc.date.available2015-08-03T14:02:20Z
dc.identifier.doi10.1371/journal.pone.0133848*


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