dc.contributor.author | Grosberg, Anna | |
dc.contributor.author | Kuo, Po-Ling | |
dc.contributor.author | Guo, Chin-Lin | |
dc.contributor.author | Geisse, Nicholas A. | |
dc.contributor.author | Bray, Mark-Anthony | |
dc.contributor.author | Adams, William J. | |
dc.contributor.author | Sheehy, Sean Paul | |
dc.contributor.author | Parker, Kevin Kit | |
dc.date.accessioned | 2015-08-10T16:52:45Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Grosberg, Anna, Po-Ling Kuo, Chin-Lin Guo, Nicholas A. Geisse, Mark-Anthony Bray, William J. Adams, Sean P. Sheehy, and Kevin Kit Parker. 2011. “Self-Organization of Muscle Cell Structure and Function.” Edited by Edmund J. Crampin. PLoS Computational Biology 7 (2) (February 24): e1001088. doi:10.1371/journal.pcbi.1001088. | en_US |
dc.identifier.issn | 1553-7358 | en_US |
dc.identifier.issn | 1553-734X | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:17985219 | |
dc.description.abstract | The organization of muscle is the product of functional adaptation over several length scales spanning from the sarcomere to the muscle bundle. One possible strategy for solving this multiscale coupling problem is to physically constrain the muscle cells in microenvironments that potentiate the organization of their intracellular space. We hypothesized that boundary conditions in the extracellular space potentiate the organization of cytoskeletal scaffolds for directed sarcomeregenesis. We developed a quantitative model of how the cytoskeleton of neonatal rat ventricular myocytes organizes with respect to geometric cues in the extracellular matrix. Numerical results and in vitro assays to control myocyte shape indicated that distinct cytoskeletal architectures arise from two temporally-ordered, organizational processes: the interaction between actin fibers, premyofibrils and focal adhesions, as well as cooperative alignment and parallel bundling of nascent myofibrils. Our results suggest that a hierarchy of mechanisms regulate the self-organization of the contractile cytoskeleton and that a positive feedback loop is responsible for initiating the break in symmetry, potentiated by extracellular boundary conditions, is required to polarize the contractile cytoskeleton. | en_US |
dc.description.sponsorship | Engineering and Applied Sciences | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science (PLoS) | en_US |
dc.relation.isversionof | doi:10.1371/journal.pcbi.1001088 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pubmed/21390276 | en_US |
dash.license | LAA | |
dc.subject | Actins | en_US |
dc.subject | Classical mechanics | en_US |
dc.subject | Cytoskeleton | en_US |
dc.subject | Integrins | en_US |
dc.subject | Muscle cell | en_US |
dc.subject | Muscle contraction | en_US |
dc.subject | Myofibrils | en_US |
dc.subject | Symmetry | en_US |
dc.title | Self-Organization of Muscle Cell Structure and Function | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS Computational Biology | en_US |
dash.depositing.author | Parker, Kevin Kit | |
dc.date.available | 2015-08-10T16:52:45Z | |
dc.identifier.doi | 10.1371/journal.pcbi.1001088 | * |
dash.contributor.affiliated | Sheehy, Sean Paul | |
dash.contributor.affiliated | Parker, Kevin | |