Browsing FAS Scholarly Articles by Author "Xavier, Ramnik J."

Now showing items 1-3 of 3

    • Akkermansia muciniphila phospholipid induces homeostatic immune responses 

      Bae, Munhyung; Cassilly, Chelsi D.; Liu, Xiaoxi; Park, Sung-Moo; Tusi, Betsabeh Khoramian; Chen, Xiangiun; Kwon, Jaeyoung; Filipcik, Pavel; Bolze, Andrew S.; Liu, Zehua; Vlamkis, Hera; Graham, Daniel B.; Buhrlage, Sara J.; Xavier, Ramnik J.; Clardy, Jon (Springer Science and Business Media LLC, 2022-07-27)
      Multiple studies have established associations between human gut bacteria and host physiology, but determining the molecular mechanisms underlying these associations has been challenging1–3. Akkermansia muciniphila has ...

    • Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense 

      Lassen, Kara G.; Kuballa, Petric; Conway, Kara L.; Patel, Khushbu K.; Becker, Christine E.; Peloquin, Joanna M.; Villablanca, Eduardo J.; Norman, Jason M.; Liu, Ta-Chiang; Heath, Robert J.; Becker, Morgan L.; Fagbami, Lola; Horn, Heiko; Mercer, Johnathan; Yilmaz, Omer H.; Jaffe, Jacob D.; Shamji, Alykhan F.; Bhan, Atul K.; Carr, Steven A.; Daly, Mark J.; Virgin, Herbert W.; Schreiber, Stuart L.; Stappenbeck, Thaddeus S.; Xavier, Ramnik J. (National Academy of Sciences, 2014)
      A coding polymorphism (Thr300Ala) in the essential autophagy gene, autophagy related 16-like 1 (ATG16L1), confers increased risk for the development of Crohn disease, although the mechanisms by which single disease-associated ...

    • Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells 

      Sundberg, Thomas B.; Choi, Hwan Geun; Song, Joo-Hye; Russell, Caitlin N.; Hussain, Mahmud M.; Graham, Daniel B.; Khor, Bernard; Gagnon, John; O’Connell, Daniel J.; Narayan, Kavitha; Dančík, Vlado; Perez, Jose R.; Reinecker, Hans-Christian; Gray, Nathanael S.; Schreiber, Stuart L.; Xavier, Ramnik J.; Shamji, Alykhan F. (National Academy of Sciences, 2014)
      Genetic alterations that reduce the function of the immunoregulatory cytokine IL-10 contribute to colitis in mouse and man. Myeloid cells such as macrophages (M Phi s) and dendritic cells (DCs) play an essential role in ...