Browsing FAS Scholarly Articles by Author "Hyde, Alan"
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Chiral Thioureas Promote Enantioselective Pictet–Spengler Cyclization by Stabilizing Every Intermediate and Transition State in the Carboxylic Acid-Catalyzed Reaction
Klausen, Rebekka; Kennedy, C. Rose; Hyde, Alan; Jacobsen, Eric (American Chemical Society (ACS), 2017-08-22)An investigation of the mechanism of benzoic acid/thiourea co-catalysis in the asymmetric Pictet-Spengler reaction is reported. Kinetic, computational, and structure-activity relationship studies provide evidence that ...