Browsing FAS Scholarly Articles by Author "Burke, Karly"

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    • BRCA1 haploinsufficiency for replication stress suppression in primary cells 

      Pathania, Shailja; Bade, Sangeeta; Le Guillou, Morwenna; Burke, Karly; Reed, Rachel; Bowman-Colin, Christian; Su, Ying; Ting, David T.; Polyak, Kornelia; Richardson, Andrea L.; Feunteun, Jean; Garber, Judy E.; Livingston, David M. (Nature Pub. Group, 2014)
      BRCA1—a breast and ovarian cancer suppressor gene—promotes genome integrity. To study the functionality of BRCA1 in the heterozygous state, we established a collection of primary human BRCA1+/+ and BRCA1mut/+ mammary ...