Browsing FAS Scholarly Articles by Author "O'Brien, Kathryn"
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Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis Raju, Ravikiran M.; Jedrychowski, Mark P.; Wei, Jun-Rong; Pinkham, Jessica T.; Park, Annie S.; O'Brien, Kathryn; Rehren, German; Schnappinger, Dirk; Gygi, Steven P.; Rubin, Eric J. (Public Library of Science, 2014)Unlike most bacterial species, Mycobacterium tuberculosis depends on the Clp proteolysis system for survival even in in vitro conditions. We hypothesized that Clp is required for the physiologic turnover of mycobacterial ...