Now showing items 1-7 of 7

    • Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle 

      Tzahor, Eldad; Kempf, Hervé; Mootoosamy, Roy C.; Poon, Andy C.; Abzhanov, Arkhat; Tabin, Clifford James; Dietrich, Susanne; Lassar, Andrew B. (Cold Spring Harbor Laboratory Press, 2003)
      Recent studies have postulated that distinct regulatory cascades control myogenic differentiation in the head and the trunk. However, although the tissues and signaling molecules that induce skeletal myogenesis in the trunk ...
    • Loss of Schooling Behavior in Cavefish through Sight-Dependent and Sight-Independent Mechanisms 

      Kowalko, Johanna Elizabeth; Rohner, Nicolas; Rompani, Santiago B.; Peterson, Brant K.; Linden, Tess Augusta; Yoshizawa, Masato; Kay, Emily H.; Weber, Jesse; Hoekstra, Hopi E.; Jeffery, William R.; Borowsky, Richard; Tabin, Clifford James (Elsevier BV, 2013)
      Background: Surface populations of Astyanax mexicanus, living in rivers like their common ancestors, school, while several, independently derived cave populations of the same species have lost schooling behavior.Results: ...
    • Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant 

      Kamberov, Yana George; Wang, Sijia; Tan, Jingze; Gerbault, Pascale; Wark, Abigail; Tan, Longzhi; Yang, Yajun; Li, Shilin; Tang, Kun; Chen, Hua; Powell, Adam; Itan, Yuval; Fuller, Dorian; Lohmueller, Jason; Mao, Junhao; Schachar, Asa; Paymer, Madeline; Hostetter, Elizabeth; Byrne, Elizabeth; Burnett, Melissa; McMahon, Andrew P.; Thomas, Mark G.; Lieberman, Daniel E.; Jin, Li; Tabin, Clifford James; Morgan, Bruce Allan; Sabeti, Pardis Christine (Elsevier BV, 2013)
      An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We have modeled EDAR370A in mice and characterized its phenotype ...
    • Multiple Phylogenetically Distinct Events Shaped the Evolution of Limb Skeletal Morphologies Associated with Bipedalism in the Jerboas 

      Moore, Talia Yuki; Organ, Chris; Edwards, Scott V.; Biewener, Andrew Austin; Tabin, Clifford James; Farish, Jenkins; Cooper, Kimberly (Elsevier BV, 2015)
      Recent rapid advances in experimental biology have expanded the opportunity for interdisciplinary investigations of the evolution of form and function in non-traditional model species. However, historical divisions of ...
    • Regulation of skeletogenic differentiation in cranial dermal bone 

      Abzhanov, Arkhat; Rodda, S. J.; McMahon, A. P.; Tabin, Clifford James (The Company of Biologists, 2007)
      Although endochondral ossification of the limb and axial skeleton is relatively well-understood, the development of dermal (intramembranous) bone featured by many craniofacial skeletal elements is not nearly as well-characterized. ...
    • A relative shift in cloacal location repositions external genitalia in amniote evolution 

      Tschopp, Patrick; Sherratt, Emma; Sanger, Thomas J.; Groner, Anna C.; Aspiras, Ariel C.; Hu, Jimmy K.; Pourquié, Olivier; Gros, Jérôme; Tabin, Clifford J. (2014)
      The move of vertebrates to a terrestrial lifestyle required major adaptations in their locomotory apparatus and reproductive organs. While the fin-to-limb transition has received considerable attention1,2, little is known ...
    • Scaling Pattern to Variations in Size during Development of the Vertebrate Neural Tube 

      Uygur, Aysu; Young, John; Huycke, Tyler R.; Koska, Mervenaz; Briscoe, James; Tabin, Clifford J. (2016)
      SUMMARY Anatomical proportions are robustly maintained in individuals that vary enormously in size, both within a species and between members of related taxa. However, the mechanisms underlying scaling are still poorly ...