Browsing FAS Scholarly Articles by FAS Department "Statistics"
Now showing items 41-60 of 187
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Context-Specific Protein Network Miner – An Online System for Exploring Context-Specific Protein Interaction Networks from the Literature
(Public Library of Science, 2012)Background: Protein interaction networks (PINs) specific within a particular context contain crucial information regarding many cellular biological processes. For example, PINs may include information on the type and ... -
A Conversation with Herman Chernoff
(Institute of Mathematical Statistics, 1996)Herman Chernoff was born in New York City on 1 July 1923. He went to school there and later received the B.S. degree from the City College of New York in 1943, majoring in mathematics with a minor in physics. For a year ... -
Cooperation between Polycomb and androgen receptor during oncogenic transformation
(Cold Spring Harbor Laboratory Press, 2011)Androgen receptor (AR) is a hormone-activated transcription factor that plays important roles in prostate development and function, as well as malignant transformation. The downstream pathways of AR, however, are incompletely ... -
Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast
(American Society for Cell Biology (ASCB), 2008)We studied the relationship between growth rate and genome-wide gene expression, cell cycle progression, and glucose metabolism in 36 steady-state continuous cultures limited by one of six different nutrients (glucose, ... -
Correlation pursuit: forward stepwise variable selection for index models
(Wiley-Blackwell, 2012)A stepwise procedure, correlation pursuit (COP), is developed for variable selection under the sufficient dimension reduction framework, in which the response variable Y is influenced by the predictors inline image through ... -
THE COUNTERNULL VALUE OF AN EFFECT SIZE: A New Statistic
(SAGE Publications, 1994)We introduce a new, readily computed statistic, the counternull value of an obtained effect size, which is the nonnull magnitude of effect size that is supported by exactly the same amount of evidence as supports the null ... -
Credible causal inference for empirical legal studies
(Annual Reviews, 2011)We review advances toward credible causal inference that have wide application for empirical legal studies. Our chief point is simple: Research design trumps methods of analysis. We explain matching and regression discontinuity ... -
Cross-fertilizing strategies for better EM mountain climbing and DA field exploration: A graphical guide book
(Institute of Mathematical Statistics, 2010)In recent years, a variety of extensions and refinements have been developed for data augmentation based model fitting routines. These developments aim to extend the application, improve the speed and/or simplify the ... -
A Data-Driven Clustering Method for Time Course Gene Expression Data
(Oxford University Press, 2006)Gene expression over time is, biologically, a continuous process and can thus be represented by a continuous function, i.e. a curve. Individual genes often share similar expression patterns (functional forms). However, the ... -
Dealing with noncompliance and missing outcomes in a randomized trial using Bayesian technology: Prevention of perinatal sepsis clinical trial, Soweto, South Africa
(Elsevier BV, 2010)The success of interventions designed to address important issues in social and medical science is best addressed by randomized experiments. With human beings there are often complications, however, such as noncompliance ... -
Decoding the H-likelihood
(Institute of Mathematical Statistics, 2009) -
Desired and feared — What do we do now and over the next 50 years?
(Informa UK Limited, 2009)An intense debate about Harvard University’s General Education Curriculum demonstrates that statistics, as a discipline, is now both desired and feared. With this new status comes a set of enormous challenges. We no longer ... -
Detecting and understanding combinatorial mutation patterns responsible for HIV drug resistance
(Proceedings of the National Academy of Sciences, 2010)We propose a systematic approach for a better understanding of how HIV viruses employ various combinations of mutations to resist drug treatments, which is critical to developing new drugs and optimizing the use of existing ... -
Dietary Fat Intake and Cognitive Decline in Women With Type 2 Diabetes
(American Diabetes Association, 2009)OBJECTIVE: Individuals with type 2 diabetes have high risk of late-life cognitive impairment, yet little is known about strategies to modify risk. Targeting insulin resistance and vascular complications—both associated ... -
Discussion of "Riemann Manifold Langevin and Hamiltonian Monte Carlo Methods"
(Royal Statistical Society, 2011) -
Discussion: One-step Sparse Estimates in Nonconcave Penalized Likelihood Models: Who Cares if It Is a White cat or a Black cat?
(Institute of Mathematical Statistics, 2008) -
Disparities in Defining Disparities: Statistical Conceptual Frameworks
(Wiley-Blackwell, 2008)Motivated by the need to meaningfully implement the Institute of Medicine's (IOM's) definition of health care disparity, this paper proposes statistical frameworks that lay out explicitly the needed causal assumptions for ... -
Dissecting the Fission Yeast Regulatory Network Reveals Phase-Specific Control Elements of Its Cell Cycle
(BioMed Central, 2009)Background: Fission yeast Schizosaccharomyces pombe and budding yeast Saccharomyces cerevisiae are among the original model organisms in the study of the cell-division cycle. Unlike budding yeast, no large-scale regulatory ... -
Effects of Xanthine Oxidase Inhibitors on Cardiovascular Disease in Patients with Gout: A Cohort Study
(Elsevier BV, 2015)BACKGROUND: Hyperuricemia and gout are associated with an increased risk of cardiovascular disease (CVD). It is unknown whether treating hyperuricemia with xanthine oxidase inhibitors (XOIs), including allopurinol and ... -
Elementary bounds on mixing times for decomposable Markov chains
(Elsevier BV, 2017-09)Many finite-state reversible Markov chains can be naturally decomposed into “projection” and “restriction” chains. In this paper we provide bounds on the total variation mixing times of the original chain in terms of the ...