Browsing FAS Scholarly Articles by Title
Now showing items 12788-12807 of 18258
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Prognostic Factors in Advanced Cancer Patients: Evidence-Based Clinical Recommendations—A Study by the Steering Committee of the European Association for Palliative Care
(American Society of Clinical Oncology (ASCO), 2005)Purpose To offer evidence-based clinical recommendations concerning prognosis in advanced cancer patients. Methods A Working Group of the Research Network of the European Association for Palliative Care identified ... -
A prognostic model of the sea-ice floe size and thickness distribution
(Copernicus GmbH, 2015)Sea ice exhibits considerable seasonal and longer-term variations in extent, concentration, thickness, and age, and is characterized by a complex and continuously changing distribution of floe sizes and thicknesses, ... -
Prognostication and Bioethics
(Massachusetts Institute of Technology Press (MIT Press), 1999) -
The Program of Gene Transcription for a Single Differentiating Cell Type During Sporulation in Bacillus Subtilis
(Public Library of Science, 2004)Asymmetric division during sporulation by Bacillus subtilis generates a mother cell that undergoes a 5-h program of differentiation. The program is governed by a hierarchical cascade consisting of the transcription factors: ... -
Programed Death is Favored by Natural Selection in Spatial Systems
(American Physical Society, 2015)Standard evolutionary theories of aging and mortality, implicitly based on mean-field assumptions, hold that programed mortality is untenable, as it opposes direct individual benefit. We show that in spatial models with ... -
Programmable biofilm-based materials from engineered curli nanofibres
(Nature Publishing Group, 2014)The significant role of biofilms in pathogenicity has spurred research into preventing their formation and promoting their disruption, resulting in overlooked opportunities to develop biofilms as a synthetic biological ... -
A programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cells
(Oxford University Press, 2016)We describe the development of ‘recCas9’, an RNA-programmed small serine recombinase that functions in mammalian cells. We fused a catalytically inactive dCas9 to the catalytic domain of Gin recombinase using an optimized ... -
Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing
(Springer Science and Business Media LLC, 2021-12-09)The targeted deletion, replacement, integration or inversion of genomic sequences could be used to study or treat human genetic diseases, but existing methods typically require double-strand DNA breaks (DSBs) that lead to ... -
Programmable diagnostic devices made from paper and tape
(Royal Society of Chemistry (RSC), 2010)This paper describes three-dimensional microfluidic paper-based analytical devices (3-D µPADs) that can be programmed (postfabrication) by the user to generate multiple patterns of flow through them. These devices are ... -
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
(2016)Current genome-editing technologies introduce double-stranded (ds) DNA breaks at a target locus as the first step to gene correction.1,2 Although most genetic diseases arise from point mutations, current approaches to point ... -
Programmable Potentials: Approximate N-body potentials from coarse-level logic
(Nature Publishing Group, 2016)This paper gives a systematic method for constructing an N-body potential, approximating the true potential, that accurately captures meso-scale behavior of the chemical or biological system using pairwise potentials coming ... -
Programmable Resistive-Switch Nanowire Transistor Logic Circuits
(American Chemical Society (ACS), 2014-08-20)Programmable logic arrays (PLA) constitute a promising architecture for developing increasingly complex and functional circuits through nanocomputers from nanoscale building blocks. Here we report a novel one-dimensional ... -
Programming colloidal phase transitions with DNA strand displacement
(American Association for the Advancement of Science (AAAS), 2015)DNA-grafted nanoparticles have been called “programmable atom-equivalents”: Like atoms, they form three-dimensional crystals, but unlike atoms, the particles themselves carry information (the sequences of the grafted ... -
Programming human pluripotent stem cells into white and brown adipocytes
(Nature Publishing Group, 2012)The utility of human pluripotent stem cells is dependent on efficient differentiation protocols that convert these cells into relevant adult cell types. Here we report the robust and efficient differentiation of human ... -
Programming Shape Using Kirigami Tessellations
(Springer Science and Business Media LLC, 2019-08-19)Kirigami tessellations are regular planar patterns formed by cutting flat, thin sheets that morph into structures with rich geometries and unusual material properties. However, geometric constraints make the development ... -
Progress and the Lack of Progress in Addressing Infant Health and Infant Health Inequalities in Ireland during the 20th Century
(2016)There is a growing literature which documents the importance of early life environment for outcomes across the life cycle. Research, including studies based on Irish data, demonstrates that those who experience better ... -
Progress in exciton spectroscopy: personal perspective
(Elsevier BV, 2000)In this Lecture, I display my personal perspective on the progress in physics of excitons during the last 50years. Preference is given to the areas of this extensive field which I participated. They include molecular ... -
Progress toward the clinical application of patient-specific pluripotent stem cells
(American Society for Clinical Investigation, 2010)Induced pluripotent stem (iPS) cells are generated by epigenetic reprogramming of somatic cells through the exogenous expression of transcription factors. These cells, just like embryonic stem cells, are likely to have a ... -
A progress-sensitive flow-sensitive inlined information-flow control monitor (extended version)
(Elsevier BV, 2017)We present a novel progress-sensitive, flow-sensitive hybrid information-flow control monitor for an imperative interactive language. Progress-sensitive information-flow control is a strong information security guarantee ...