Browsing FAS Scholarly Articles by Title

Now showing items 1955-1974 of 18292

    • Characterization of Bipolar Disorder Patient-Specific Induced Pluripotent Stem Cells from a Family Reveals Neurodevelopmental and mRNA Expression Abnormalities 

      Madison, Jon M.; Zhou, Fen; Nigam, Aparna; Hussain, Ali; Barker, Douglas D.; Nehme, Ralda; van der Ven, Karlijn; Hsu, Jenny; Wolf, Pavlina; Fleishman, Morgan; O’Dushlaine, Colm; Rose, Sam; Chambert, Kimberly; Lau, Frank H.; Ahfeldt, Tim; Rueckert, Erroll H.; Sheridan, Steven D.; Fass, Daniel M.; Nemesh, James; Mullen, Thomas E.; Daheron, Laurence; McCarroll, Steve; Sklar, Pamela; Perlis, Roy H.; Haggarty, Stephen J. (2014)
      Bipolar disorder (BD) is a common neuropsychiatric disorder characterized by chronic recurrent episodes of depression and mania. Despite evidence for high heritability of BD, little is known about its underlying pathophysiology. ...

    • Characterization of chemoautotrophic bacterial symbionts in a gutless marine worm (Oligochaeta, Annelida) by phylogenetic 16S rRNA sequence analysis and in situ hybridization 

      Dubilier, N; Giere, O; Distel, D L; Cavanaugh, Colleen Marie (American Society for Microbiology, 1995)
      The phylogenetic relationships of chemoautotrophic endosymbionts in the gutless marine oligochaete Inanidrilus leukodermatus to chemoautotrophic ecto- and endosymbionts from other host phyla and to free-living bacteria ...

    • Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer 

      Terai, Hideki; Tan, Li; Beauchamp, Ellen M.; Hatcher, John M.; Liu, Qingsong; Meyerson, Matthew; Gray, Nathanael S.; Hammerman, Peter S. (American Chemical Society, 2015)
      Despite advances in precision medicine approaches over the past decade, the majority of nonsmall cell lung cancers (NSCLCs) are refractory to treatment with targeted small molecule inhibitors. Previous work has identified ...

    • Characterization of Endostatin Binding to Heparin and Heparan Sulfate by Surface Plasmon Resonance and Molecular Modeling Role of Divalent Cations 

      Ricard-Blum, Sylvie; Féraud, Olivier; Lortat-Jacob, Hugues; Rencurosi, Anna; Fukai, Naomi; Dkhissi, Fatima; Vittet, Daniel; Imberty, Anne; Olsen, Bjorn; Van Der Rest, Michel (American Society for Biochemistry and Molecular Biology, 2004)
      Endostatin (20 kDa) is a C-terminal proteolytic fragment of collagen XVIII that is localized in vascular basement membrane zones in various organs. It binds zinc, heparin/heparan sulfate, laminin, and sulfatides and inhibits ...

    • Characterization of immune-matched hematopoietic transplantation in zebrafish 

      de Jong, J. L. O.; Burns, Caroline Erter; Chen, A. T.; Pugach, E.; Mayhall, E. A.; Smith, A. C. H.; Feldman, Henry Arthur; Zhou, Yi; Zon, Leonard Ira (American Society of Hematology, 2011)
      Evaluating hematopoietic stem cell (HSC) function in vivo requires a long-term transplantation assay. Although zebrafish are a powerful model for discovering the genetics of hematopoiesis, hematopoietic transplantation ...

    • Characterization of Individual Polynucleotide Molecules Using a Membrane Channel 

      Kasianowicz, John J.; Brandin, Eric; Branton, Daniel; Deamer, David W. (National Academy of Sciences of the United States of America, 1996)
      We show that an electric field can drive single-stranded RNA and DNA molecules through a 2.6-nm diameter ion channel in a lipid bilayer membrane. Because the channel diameter can accommodate only a single strand of RNA or ...

    • Characterization of Iron-Imido Species Relevant forN-Group Transfer Chemistry 

      Iovan, Diana Alexandra; Betley, Theodore A (American Chemical Society (ACS), 2016)
      A sterically accessible tert-butyl-substituted dipyrrinato di-iron(II) complex [(tBuL)FeCl]2 possessing two bridging chloride atoms was synthesized from the previously reported solvento adduct. Upon treatment with aryl ...

    • Characterization of Nucleic Acids by Nanopore Analysis 

      Deamer, David W.; Branton, Daniel (American Chemical Society, 2002)
      Single-stranded DNA and RNA molecules in solution can be driven through a nanoscopic pore by an applied electric field. As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information ...

    • Characterization of the Benchmark Binary Nltt 33370 

      Schlieder, Joshua E.; Bonnefoy, Mickaël; Herbst, T. M.; Lépine, Sébastien; Berger, Edo; Henning, Thomas; Skemer, Andrew; Chauvin, Gaël; Rice, Emily; Biller, Beth; Girard, Julien H. V.; Lagrange, Anne-Marie; Hinz, Philip; Defrère, Denis; Bergfors, Carolina; Brandner, Wolfgang; Lacour, Sylvestre; Skrutskie, Michael; Leisenring, Jarron (IOP Publishing, 2014)
      We report the confirmation of the binary nature of the nearby, very low-mass system NLTT 33370 with adaptive optics imaging and present resolved near-infrared photometry and integrated light optical and near-infrared ...

    • Characterization of the BICEP Telescope for High-precision Cosmic Microwave Background Polarimetry 

      Takahashi, Yuki D.; Ade, Peter; Barkats, Denis; Battle, John O.; Bierman, Evan M.; Bock, James; Chiang, H. Cynthia; Dowell, C. Darren; Duband, Lionel; Hivon, Eric F.; Holzapfel, William L.; Hristov, Victor V.; Jones, William C.; Keating, Brian G.; Kovac, John M; Kuo, Chao-Lin; Lange, Andrew E.; Leitch, Erik M.; Mason, Peter V.; Matsumura, Tomotake; Nguyen, Hien T.; Ponthieu, N.; Pryke, Clement; Richter, Steffen; Rocha, Graca M.; Yoon, Ki Won (IOP Publishing, 2010)
      The Background Imaging of Cosmic Extragalactic Polarization (BICEP) experiment was designed specifically to search for the signature of inflationary gravitational waves in the polarization of the cosmic microwave background ...

    • Characterization of the Filum terminale as a neural progenitor cell niche in both rats and humans 

      Chrenek, Ryan; Magnotti, Laura M.; Herrera, Gabriella R.; Jha, Ruchira M.; Cardozo, David L. (John Wiley and Sons Inc., 2016)
      Abstract Neural stem cells (NSCs) reside in a unique microenvironment within the central nervous system (CNS) called the NSC niche. Although they are relatively rare, niches have been previously characterized in both the ...

    • Characterization of the HD 17156 Planetary System 

      Barbieri, M.; Alonso, R.; Desidera, S.; Sozzetti, A.; Martinez Fiorenzano, A.F.; Almenara, J.M.; Cecconi, M.; Claudi, R.U.; Endl, M.; Granata, V.; Gratton, R.; Laughlin, G.; Loeillet, B.; Charbonneau, David (EDP Sciences, 2009)
      Aims. We present data to improve the known parameters of the HD 17156 system (peculiar due to the eccentricity and long orbital period of its transiting planet) and constrain the presence of stellar companions. Methods. ...

    • Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation 

      Mooij, Marlies J.; Drenkard, Eliana; Llamas, María A.; Vandenbroucke-Grauls, Christina M. J. E.; Savelkoul, Paul H. M.; Ausubel, Frederick M.; Bitter, Wilbert (Society for General Microbiology, 2007)
      Bacteriophages play an important role in bacterial virulence and phenotypic variation. It has been shown that filamentous bacteriophage Pf4 of Pseudomonas aeruginosa strain PAO1 mediates the formation of small-colony ...

    • Characterization of the Millimeter-Wave Polarization of Centaurus A with QUaD 

      Zemcov, Michael B.; Ade, Peter; Bock, James; Bowden, Melanie; Brown, Michael L.; Cahill, Gary; Castro, Patricia G.; Church, Sarah; Culverhouse, Thomas; Friedman, Robert B.; Ganga, Ken; Gear, Walter K.; Gupta, Sujata; Hinderks, James; Kovac, John M; Lange, Andrew E.; Leitch, Erik; Melhuish, Simon J.; Memari, Yasin; Murphy, J. Anthony; Orlando, Angiola; O’ Sullivan, Creidhe; Piccirillo, Lucio; Pryke, Clem; Rajguru, Nutan; Rusholme, Ben; Schwarz, Robert; Taylor, Andrew N.; Thompson, Keith L.; Turner, Abigail H.; Wu, Ed Y. S. (IOP Publishing, 2010)
      Centaurus (Cen) A represents one of the best candidates for an isolated, compact, highly polarized source that is bright at typical cosmic microwave background (CMB) experiment frequencies. We present measurements of the ...

    • Characterization of the OCO-2 instrument line shape functions using on-orbit solar measurements 

      Sun, Kang; Liu, Xiong; Nowlan, Caroline R.; Cai, Zhaonan; Chance, Kelly; Frankenberg, Christian; Lee, Richard A. M.; Pollock, Randy; Rosenberg, Robert; Crisp, David (European Geosciences Union, 2017)
      Accurately characterizing the instrument line shape (ILS) of the Orbiting Carbon Observatory-2 (OCO-2) is challenging and highly important due to its high spectral resolution and requirement for retrieval accuracy (0 : ...

    • Characterization of the planetary system Kepler-101 with HARPS-N - A hot super-Neptune with an Earth-sized low-mass companion 

      Bonomo, A. S.; Sozzetti, A.; Lovis, C.; Malavolta, L.; Rice, K.; Buchhave, L. A.; Sasselov, D.; Cameron, A. C.; Latham, D. W.; Molinari, E.; Pepe, F.; Udry, S.; Affer, L.; Charbonneau, D.; Cosentino, R.; Dressing, C. D.; Dumusque, X.; Figueira, P.; Fiorenzano, A. M.; Gettel, S.; Harutyunyan, A.; Haywood, R. D.; Horne, K.; Lopez-Morales, M.; Mayor, M.; Micela, G.; Motalebi, F.; Nascimbeni, V.; Phillips, D. F.; Piotto, G.; Pollacco, D.; Queloz, D.; Ségransan, D.; Szentgyorgyi, A.; Watson, C. (EDP Sciences, 2014)
      We characterize the planetary system Kepler-101 by performing a combined differential evolution Markov chain Monte Carlo analysis of Kepler data and forty radial velocities obtained with the HARPS-N spectrograph. This ...

    • Characterization of the Praesepe Star Cluster by Photometry and Proper Motions With 2MASS, PPMXL, and Pan-STARRS 

      Wang, Ping; Chen, Wei; Lin, C. C.; Pandey, A. K.; Huang, C. K.; Panwar, N.; Lee, C. H.; Tsai, M. F.; Tang, C.-H.; Goldman, B.; Burgett, W. S.; Chambers, K. C.; Draper, P. W.; Flewelling, H.; Grav, T.; Heasley, J. N.; Hodapp, K. W.; Huber, M. E.; Jedicke, R.; Kaiser, N.; Kudritzki, R.-P.; Luppino, G. A.; Lupton, R. H.; Magnier, E. A.; Metcalfe, N.; Monet, D. G.; Morgan, J. S.; Onaka, P. M.; Price, P. A.; Stubbs, Christopher William; Sweeney, W.; Tonry, J. L.; Wainscoat, R. J.; Waters, C. (IOP Publishing, 2014)
      Membership identification is the first step in determining the properties of a star cluster. Low-mass members in particular could be used to trace the dynamical history, such as mass segregation, stellar evaporation, or ...

    • Characterization of Topological States on a Lattice with Chern Number 

      Hafezi, Mohammad; Sørensen, Anders; Lukin, Mikhail D.; Demler, Eugene A. (Institute of Physics, 2008)
      We study Chern numbers to characterize the ground state of strongly interacting systems on a lattice. This method allows us to perform a numerical characterization of bosonic fractional quantum Hall (FQH) states on a lattice ...

    • Characterizing Cancer Subtypes Using Dual Analysis in Caleydo StratomeX 

      Turkay, Cagatay; Lex, Alexander; Streit, Marc; Pfister, Hanspeter; Hauser, Helwig (Institute of Electrical and Electronics Engineers (IEEE), 2014-03)
      In this approach, dual-analysis views depict distributions of genes or data samples within Caleydo. Significant-difference plots show the elements of a cancer subtype that differ significantly from other subtypes. Analysts ...

    • Characterizing Concentrated, Multiply Scattering, and Actively Driven Fluorescent Systems with Confocal Differential Dynamic Microscopy 

      Lu, Peter J.; Giavazzi, Fabio; Angelini, Thomas E.; Zaccarelli, Emanuela; Jargstorff, Frank; Schofield, Andrew B.; Wilking, James N.; Romanowsky, Mark B.; Weitz, David A.; Cerbino, Roberto (American Physical Society, 2012)