Now showing items 3807-3826 of 18292

    • Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human 

      Zhang, Kun; Li, Jin Billy; Gao, Yuan; Egli, Dieter; Xie, Bin; Deng, Jie; Li, Zhe; Lee, Je-Hyuk; Aach, John Dennis; Leproust, Emily M; Eggan, Kevin Carl; Church, George McDonald (Nature Publishing Group, 2009)
      We developed a digital RNA allelotyping method for quantitatively interrogating allele-specific gene expression. This method involves ultra-deep sequencing of padlock captured SNPs from the transcriptome. We characterized ...
    • Digital RNA Sequencing Minimizes Sequence-Dependent Bias and Amplification Noise with Optimized Single-Molecule Barcodes 

      Shiroguchi, Katsuyuki; Jia, Tony Z; Sims, Peter A.; Xie, Xiaoliang Sunney (Proceedings of the National Academy of Sciences, 2012)
      RNA sequencing (RNA-Seq) is a powerful tool for transcriptome profiling, but is hampered by sequence-dependent bias and inaccuracy at low copy numbers intrinsic to exponential PCR amplification. We developed a simple ...
    • Dignifying the Guerrillero, Not the Assassin: Rewriting a History of Criminal Subversion in Postwar Guatemala 

      Weld, Kirsten A. (Duke University Press, 2012)
      This article examines an understudied aspect of Guatemala's Cold War counter-insurgency campaign: the concerted effort to destroy the seeds of oppositional thinking by criminalizing any and all forms of dissent, both during ...
    • Dijet production in s√=7 TeV pp collisions with large rapidity gaps at the ATLAS experiment 

      Clark, Brian Lee; Franklin, Melissa; Huth, John; Ippolito, Valerio; Lazovich, Tomo; Lopez Mateos, David; Mercurio, Kevin; Morii, Masahiro; Spearman, William; Sun, Siyuan; Tolley, Emma; Tuna, Alexander; Yen, Andy; Zambito, Stefano (Elsevier BV, 2016)
      A 6.8 nb−1 sample of pp collision data collected under low-luminosity conditions at s√=7 TeV by the ATLAS detector at the Large Hadron Collider is used to study diffractive dijet production. Events containing at least two ...
    • Dijet Searches for Supersymmetry at the Large Hadron Collider 

      Randall, Lisa; Tucker-Smith, David (American Physical Society, 2008)
      We present several strategies for searching for supersymmetry in dijet channels that do not explicitly invoke missing energy. Preliminary investigations suggest that signal-to-background ratios of at least 4--5 should be ...
    • Dilatant Strengthening as a Mechanism for Slow Slip Events 

      Segall, Paul; Rubin, Allan M.; Bradley, Andrew M.; Rice, James R. (American Geophysical Union, 2010)
      The mechanics of slow slip events (SSE) in subduction zones remain unresolved. We suggest that SSE nucleate in areas of unstable friction under drained conditions, but as slip accelerates dilatancy reduces pore pressure ...
    • Dimer Models from Mirror Symmetry and Quivering Amoebae 

      Feng, Bo; He, Yang-Hui; Kennaway, Kristian D.; Vafa, Cumrun (International Press, 2008)
      Dimer models are 2-dimensional combinatorial systems that have been shown to encode the gauge groups, matter content and tree-level super-potential of the world-volume quiver gauge theories obtained by placing D3-branes ...
    • Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio) 

      Uribe, Phillip M.; Mueller, Melissa; Gleichman, Julia S.; Kramer, Matthew; Wang, Qi; Sibrian-Vazquez, Martha; Strongin, Robert M.; Steyger, Peter S.; Cotanche, Douglas; Matsui, Jonathan I. (Public Library of Science, 2013)
      Inner ear sensory hair cells die following exposure to aminoglycoside antibiotics or chemotherapeutics like cisplatin, leading to permanent auditory and/or balance deficits in humans. Zebrafish (Danio rerio) are used to ...
    • Dimetrodon: Processor-level Preventive Thermal Management via Idle Cycle Injection 

      Bailis, Peter; Reddi, Vijay Janapa; Gandhi, Sanjay; Brooks, David M.; Seltzer, Margo I. (ACM, 2011)
      Processor-level dynamic thermal management techniques have long targeted worst-case thermal margins. We examine the thermal-performance trade-offs in average-case, preventive thermal management by actively degrading ...
    • Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration 

      Painter, Michio Wendell; Brosius Lutz, Amanda; Cheng, Yung-Chih; Latremoliere, Alban; Duong, Kelly; Miller, Christine; Posada, Sean; Cobos, Enrique J.; Zhang, Alan; Wagers, Amy Jo; Havton, Leif A.; Barres, Ben; Omura, Takao; Woolf, Clifford (Elsevier BV, 2014)
      The regenerative capacity of the peripheral nervous system declines with age. Why this occurs, however, is unknown. We demonstrate that 24-month-old mice exhibit an impairment of functional recovery after nerve injury ...
    • Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation 

      Chou, H.-H.; Chiu, H.-C.; Delaney, N. F.; Segre, D.; Marx, Christopher J (American Association for the Advancement of Science (AAAS), 2011)
      Epistasis has substantial impacts on evolution, in particular, the rate of adaptation. We generated combinations of beneficial mutations that arose in a lineage during rapid adaptation of a bacterium whose growth depended ...
    • Dimpled elastic sheets: a new class of non-porous negative Poisson’s ratio materials 

      Javid, Farhad; Smith-Roberge, Evelyne; Innes, Matthew C.; Shanian, Ali; Weaver, James C.; Bertoldi, Katia (Nature Publishing Group, 2015)
      In this study, we report a novel periodic material with negative Poisson’s ratio (also called auxetic materials) fabricated by denting spherical dimples in an elastic flat sheet. While previously reported auxetic materials ...
    • Dinitrosyl formation as an intermediate stage of the reduction of NO in the presence of MoO3 

      Remediakis, Ioannis N.; Kaxiras, Efthimios; Chen, Melvin; Friend, Cynthia M. (AIP Publishing, 2003)
      We present first-principles calculations in the framework of density-functional theory and the pseudopotential approach, aiming to model the intermediate stages of the reduction of NO in the presence of MoO3(010). In ...
    • A Dinuclear Palladium Catalyst for \(\alpha\)-Hydroxylation of Carbonyls with \(O_2\) 

      Chuang, Gary Jing; Wang, Weike; Lee, Eunsung; Ritter, Tobias (American Chemical Society, 2011)
      A chemo- and regioselective \(\alpha\)-hydroxylation reaction of carbonyl compounds with molecular oxygen as oxidant is reported. The hydroxylation reaction is catalyzed by a dinuclear Pd(II) complex, which functions as ...
    • Diophantine and Ergodic Foliations on Surfaces 

      McMullen, Curtis T. (Oxford University Press, 2012-11-16)
    • A diphoton resonance from bulk RS 

      Csáki, Csaba; Randall, Lisa (Springer Nature, 2016)
      Recent LHC data hinted at a 750 GeV mass resonance that decays into two photons. A significant feature of this resonance is that its decays to any other Standard Model particles would be too low to be detected so far. Such ...
    • Dipolar modeling and experimental demonstration of multi-beam plasmonic collimators 

      Tetienne, J-P.; Blanchard, R.; Yu, N.; Genevet, P.; Kats, M. A.; Fan, J. A.; Edamura, T.; Furuta, S.; Yamanishi, M.; Capasso, F. (IOP Publishing, 2011)
      We designed a new class of plasmonic gratings that generate multiple free-space beams in arbitrary directions from a point source of surface waves, using a phenomenological model that accurately predicts their far-field, ...
    • Dipolar spin-exchange and entanglement between molecules in an optical tweezer array 

      Bao, Yicheng; Yu, Scarlett S.; Anderegg, Loic; Chae, Eunmi; Ketterle, Wolfgang; Ni, Kang-Kuen; Doyle, John M. (American Association for the Advancement of Science (AAAS), 2023-12-08)
      Ultracold polar molecules are promising candidate qubits for quantum computing and quantum simulations. Their long-lived molecular rotational states form robust qubits and the long-range dipolar interaction between molecules ...
    • Dipole Properties of Molecular Hydrogen 

      Victor, G. A.; Dalgarno, Alexander (AIP Publishing, 1969)
      Experimental data on electron scattering, optical refractivity, and molecular anisotropy are used to construct a model dipole spectrum for molecular hydrogen which is consistent with oscillator‐strength sum rules. The model ...