Browsing FAS Scholarly Articles by Title
Now showing items 4030-4049 of 18292
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Distinct bone marrow blood vessels differentially regulate haematopoiesis
(Springer Nature, 2016)Bone marrow (BM) endothelial cells (BMECs) form a network of blood vessels (BVs) which regulate both leukocyte trafficking and hematopoietic stem and progenitor cell (HSPC) maintenance. However, it is not clear how BMECs ... -
Distinct Cerebral Pathways for Object Identity and Number in Human Infants
(Public Library of Science, 2008)All humans, regardless of their culture and education, possess an intuitive understanding of number. Behavioural evidence suggests that numerical competence may be present early on in infancy. Here, we present brain-imaging ... -
Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip
(Public Library of Science, 2016)Neurovascular inflammation is a major contributor to many neurological disorders, but modeling these processes in vitro has proven to be difficult. Here, we microengineered a three-dimensional (3D) model of the human ... -
Distinct Cortical Anatomy Linked to Subregions of the Medial Temporal Lobe Revealed by Intrinsic Functional Connectivity
(American Physiological Society, 2008)The hippocampus and adjacent cortical structures in the medial temporal lobe (MTL) contribute to memory through interactions with distributed brain areas. Studies of monkey and rodent anatomy suggest that parallel pathways ... -
Distinct effectors of platelet-derived growth factor receptor-α signaling are required for cell survival during embryogenesis
(National Academy of Sciences, 2005)Platelet-derived growth factor receptor (PDGFR) signaling is essential for normal embryonic development in many organisms, including frog, mouse, zebrafish, and sea urchin. The mode of action of PDGFR signaling during early ... -
Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion
(eLife Sciences Publications, Ltd, 2015)Membrane fusion is the critical step for infectious cell penetration by enveloped viruses. We have previously used single-virion measurements of fusion kinetics to study the molecular mechanism of influenza-virus envelope ... -
Distinct Malignant Behaviors of Mouse Myogenic Tumors Induced by Different Oncogenetic Lesions
(Frontiers Media S.A., 2015)Rhabdomyosarcomas (RMS) are heterogeneous cancers with myogenic differentiation features. The cytogenetic and mutational aberrations in RMS are diverse. This study examined differences in the malignant behavior of two ... -
Distinct Mechanisms for the Activation of the RSK kinases/MAP2 Kinase/pp90rsk and Pp70-S6 Kinase Signaling Systems Are Indicated by Inhibition of Protein Synthesis
(1991)Previous studies demonstrated that addition of protein synthesis inhibitors to quiescent cells resulted in the stimulation of S6 kinase activity. The present characterization of several growth factor- and oncogene-regulated ... -
Distinct Properties of \(Ca^{2+}\)-Calmodulin Binding to N- and C-Terminal Regulatory Regions of the TRPV1 Channel
(Rockefeller University Press, 2012)Transient receptor potential (TRP) vanilloid 1 (TRPV1) is a molecular pain receptor belonging to the TRP superfamily of nonselective cation channels. As a polymodal receptor, TRPV1 responds to heat and a wide range of ... -
Distinct Regions of Right Temporal Cortex Are Associated with Biological and Human-Agent Motion: Functional Magnetic Resonance Imaging and Neuropsychological Evidence
(Society for Neuroscience, 2013)In human lateral temporal cortex, some regions show specific sensitivity to human motion. Here we examine whether such effects reflect a general biological-nonbiological organizational principle or a process specific to ... -
Distinct Signatures for Coulomb Blockade and Aharonov-Bohm Interference in Electronic Fabry-Perot Interferometers
(American Physical Society, 2009)Two distinct types of magnetoresistance oscillations are observed in two electronic Fabry-Perot interferometers of different sizes in the integer quantum Hall regime. Measuring these oscillations as a function of magnetic ... -
Distinct Spatiotemporal Activity in Principal Neurons of the Mouse Olfactory Bulb in Anesthetized and Awake States
(Frontiers Media S.A., 2013)The acquisition of olfactory information and its early processing in mammals are modulated by brain states through sniffing behavior and neural feedback. We imaged the spatiotemporal pattern of odor-evoked activity in a ... -
Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation
(The Rockefeller University Press, 2014)The zinc finger transcriptional repressor Gfi-1b is essential for erythroid and megakaryocytic development in the embryo. Its roles in the maintenance of bone marrow erythropoiesis and thrombopoiesis have not been defined. ... -
Distinctive Encoding Reduces the Jacoby-Whitehouse Illusion
(Psychonomic Society, 2008)We investigated the influence of distinctive encoding on the Jacoby and Whitehouse (1989) illusion. Subjects studied visually presented words that were associated with either an auditory presentation of the same word ... -
Distinctive Neural Mechanisms Supporting Visual Object Individuation and Identification
(MIT Press, 2009)Many everyday activities, such as driving on a busy street, require the encoding of distinctive visual objects from crowded scenes. Given resource limitations of our visual system, one solution to this difficult and ... -
Distinguishing black holes from naked singularities through their accretion disc properties
(IOP Publishing, 2013)We show that, in principle, a slowly evolving gravitationally collapsing perfect fluid cloud can asymptotically settle to a static spherically symmetric equilibrium configuration with a naked singularity at the center. We ... -
Distortion of gravitational-wave packets due to their self-gravity
(American Physical Society, 2007)When a source emits a gravity-wave (GW) pulse over a short period of time, the leading edge of the GW signal is redshifted more than the inner boundary of the pulse. The GW pulse is distorted by the gravitational effect ... -
The Distortion of the Cosmic Microwave Background Spectrum Due to Intergalactic Dust
(American Astronomical Society, 2016)Infrared emission from intergalactic dust might compromise the ability of future experiments to detect subtle spectral distortions in the Cosmic Microwave Background (CMB) from the early Universe. We provide the first ... -
Distortion of the Luminosity Function of High-redshift Galaxies by Gravitational Lensing
(American Astronomical Society, 2015)The observed properties of high - redshift galaxies depend on the underlying foreground distribution of large - scale structure, which distorts their intrinsic properties via gravitational lensing. We focus on the regime ... -
Distortions of Mind Perception in Psychopathology
(Proceedings of the National Academy of Sciences, 2010)It has long been known that psychopathology can influence social perception, but a 2D framework of mind perception provides the opportunity for an integrative understanding of some disorders. We examined the covariation ...