Browsing FAS Scholarly Articles by Title
Now showing items 4919-4938 of 18292
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Energy-Resolved Positron Annihilation in Flight in Solid Targets
(American Physical Society (APS), 1999)Energy-resolved two-quantum annihilation in flight of positrons with energies ranging from 10 to 71.6 keV was observed. An energy-dispersive two-detector coincidence system was used to observe the sum and difference energies ... -
Enforced Presentation of an Extrahelical Guanine to the Lesion Recognition Pocket of Human 8-Oxoguanine Glycosylase, hOGG1
(American Society for Biochemistry and Molecular Biology, 2012)A poorly understood aspect of DNA repair proteins is their ability to identify exceedingly rare sites of damage embedded in a large excess of nearly identical undamaged DNA, while catalyzing repair only at the damaged ... -
Enforcement Is Central to the Evolution of Cooperation
(Springer Science and Business Media LLC, 2019-06-24)Cooperation occurs at all levels of life, from genomes, complex cells and multicellular organisms to societies and mutualisms between species. A major question for evolutionary biology is what these diverse systems have ... -
Enforcement of Civil Rights Law in Private Workplaces: The Effects of Compliance Reviews and Lawsuits Over Time
(Wiley-Blackwell, 2006)Has federal antidiscrimination law been effective in moving women and minorities into management? Early studies show that government affirmative action reviews improved the numbers, and rank, of blacks, but evidence of ... -
Engagement, Gentrification, and the Neoliberal Hijacking of History
(University of Chicago Press, 2010)Drawing primarily on fieldwork in Greece, Italy, and Thailand, I examine the use of historic conservation to justify gentrification. This commoditization of history expands into urban design a classification that serves ... -
Engaging Students through Video: Integrating Assessment and Instrumentation
(Association for Computing Machinery, 2013)CS50 is Harvard’s introductory course for majors and non-majors alike. For years, we have posted videos of the course’s lectures and sections online for the sake of review and distance education alike. But students’ ... -
Engaging the Motor System with Masked Orthographic Primes: A Kinematic Analysis
(Taylor & Francis, 2008)We report two experiments in which participants categorized target words (e. g., BLOOD or CUCUMBER) according to their canonical colour of red or green by pointing to a red square on the left or a green square on the right. ... -
An Engineered Bivalent Neuregulin Protects Against Doxorubicin-Induced Cardiotoxicity With Reduced Proneoplastic Potential
(Ovid Technologies (Wolters Kluwer Health), 2013)Background—Doxorubicin (DOXO) is an effective anthracycline chemotherapeutic, but its use is limited by cumulative dose-dependent cardiotoxicity. Neuregulin-1β is an ErbB receptor family ligand that is effective against ... -
An Engineered Calmodulin-Based Allosteric Switch for Peptide Biosensing
(Wiley Blackwell (John Wiley & Sons), 2013)This work describes the development of a new platform for allosteric protein engineering that takes advantage of the ability of calmodulin to change conformation upon binding to peptide and protein ligands. The switch we ... -
Engineered catalytic biofilms: Site-specific enzyme immobilization onto E. coli curli nanofibers
(Wiley-Blackwell, 2015)Biocatalytic transformations generally rely on purified enzymes or whole cells to perform complex transformations that are used on industrial scale for chemical, drug, and biofuel synthesis, pesticide decontamination, and ... -
Engineered Hyperactive Integrase for Concerted HIV-1 DNA Integration
(Public Library of Science, 2014)The DNA cutting and joining reactions of HIV-1 integration are catalyzed by integrase (IN), a viral protein that functions as a tetramer bridging the two viral DNA ends (intasome). Two major obstacles for biochemical and ... -
Engineered Living Materials: Engineered Living Materials: Prospects and Challenges for Using Biological Systems to Direct the Assembly of Smart Materials
(Wiley, 2018-05)Vast potential exists for the development of novel, engineered platforms that manipulate biology for the production of programmed advanced materials. Such systems would possess the autonomous, adaptive, and self‐healing ... -
Engineered Myosins Drive Filopodial Transport
(Springer Science and Business Media LLC, 2021-02-01)Engineered, light-inducible artificial myosin motors enable selective and direct manipulation of filopodial extensions and provide refined tools to control intracellular cargo transport in vivo. -
Engineered pegRNAs improve prime editing efficiency
(Springer Science and Business Media LLC, 2021-10-04)Prime editing enables the installation of virtually any combination of point mutations, small insertions or small deletions in the DNA of living cells. A prime editing guide RNA (pegRNA) directs the prime editor protein ... -
Engineering acyl carrier protein to enhance production of shortened fatty acids
(BioMed Central, 2016)Background: The acyl carrier protein (ACP) is an essential and ubiquitous component of microbial synthesis of fatty acids, the natural precursor to biofuels. Natural fatty acids usually contain long chains of 16 or more ... -
Engineering and Identifying Supercharged Proteins for Macromolecule Delivery Into Mammalian Cells
(Elsevier BV, 2012)Supercharged proteins are a class of engineered or naturally occurring proteins with unusually high net positive or negative theoretical charge. Both supernegatively and superpositively charged proteins exhibit a remarkable ... -
Engineering Directed Excitonic Energy Transfer
(American Institute of Physics, 2010)We provide an intuitive platform for engineering exciton transfer dynamics. We show that careful consideration of the spectral density, which describes the system-bath interaction, leads to opportunities to engineer exciton ... -
Engineering Escherichia coli into a Protein Delivery System for Mammalian Cells
(American Chemical Society, 2015)Many Gram-negative pathogens encode type 3 secretion systems, sophisticated nanomachines that deliver proteins directly into the cytoplasm of mammalian cells. These systems present attractive opportunities for therapeutic ... -
Engineering Genetically-Encoded Mineralization and Magnetism via Directed Evolution
(Nature Publishing Group, 2016)Genetically encoding the synthesis of functional nanomaterials such as magnetic nanoparticles enables sensitive and non-invasive biological sensing and control. Via directed evolution of the natural iron-sequestering ... -
Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR
(2016)Recurrent, reciprocal genomic disorders resulting from non-allelic homologous recombination (NAHR) between near-identical segmental duplications (SDs) are a major cause of human disease, often producing phenotypically ...