Browsing FAS Scholarly Articles by FAS Department "Stem Cell and Regenerative Biology"
Now showing items 21-40 of 187
-
Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity
(Society for Neuroscience, 2016)The neocortex contains hundreds to thousands of distinct subtypes of precisely connected neurons, allowing it to perform remarkably complex tasks of high-level cognition. Callosal projection neurons (CPN) connect the ... -
Common Genetic Variation at the IL1RL1 Locus Regulates IL-33/ST2 Signaling
(American Society for Clinical Investigation, 2013)The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms. The membrane-bound isoform (ST2L) induces an immune response ... -
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits
(Springer Science and Business Media LLC, 2020-11-23)Genome-wide association studies (GWAS) reveal genomic variants associated with human traits and diseases. Most trait-associated variants are located within cell type-specific enhancers, but the molecular mechanism by which ... -
Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons
(Elsevier BV, 2011)The mammalian nervous system is composed of a multitude of distinct neuronal subtypes, each with its own phenotype and differential sensitivity to degenerative disease. Although specific neuronal types can be isolated from ... -
Corticospinal Motor Neurons and Related Subcerebral Projection Neurons Undergo Early and Specific Neurodegeneration in \(hSOD1^{G93A}\) Transgenic ALS Mice
(Society for Neuroscience, 2011)Amyotrophic lateral sclerosis (ALS) is characterized by predominant vulnerability and central degeneration of both corticospinal/corticobulbar motor neurons (CSMN; “upper motor neurons”) in cerebral cortex, and spinal/bulbar ... -
Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function
(Oxford University Press, 2015)Corticospinal motor neurons (CSMN) receive, integrate, and relay cerebral cortex's input toward spinal targets to initiate and modulate voluntary movement. CSMN degeneration is central for numerous motor neuron disorders ... -
Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
(Springer Science and Business Media LLC, 2021-03-31)Chronic, sustained exposure to stressors can profoundly impact tissue homeostasis, although the mechanisms by which these changes occur are largely unknown. Here, we report the adrenal gland-derived stress hormone ... -
Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity
(Elsevier BV, 2016)Corticothalamic projection neurons (CThPN) are a diverse set of neurons, critical for function of the neocortex. CThPN development and diversity need to be precisely regulated, but little is known about molecular controls ... -
Cross-circulation and cell distribution kinetics in parabiotic mice
(Wiley-Blackwell, 2011)Blood-borne nucleated cells participate not only in inflammation, but in tissue repair and regeneration. Because progenitor and stem cell populations have a low concentration in the blood, the circulation kinetics and ... -
Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex
(Elsevier BV, 2016)While several transcriptional controls over the size and relative position of cortical areas have been identified, less is known about regulators that direct acquisition of area-specific characteristics. Here, we report ... -
Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers
(Elsevier BV, 2016)The molecular linkage between neocortical projection neuron subtype and area development, which enables the establishment of functional areas by projection neuron populations appropriate for specific sensory and motor ... -
Ctip2 Controls the Differentiation of Medium Spiny Neurons and the Establishment of the Cellular Architecture of the Striatum
(Society for Neuroscience, 2008)Striatal medium spiny neurons (MSN) are critically involved in motor control, and their degeneration is a principal component of Huntington's disease. We find that the transcription factor Ctip2 (also known as Bcl11b) is ... -
Deciphering Amyotrophic Lateral Sclerosis: What Phenotype, Neuropathology and Genetics Are Telling Us about Pathogenesis
(Informa, 2013)Amyotrophic lateral sclerosis (ALS) is characterized phenotypically by progressive weakness and neuropathologically by loss of motor neurons. Phenotypically, there is marked heterogeneity. Typical ALS has mixed upper motor ... -
Delivering Heparin-Binding Insulin-Like Growth Factor 1 with Self-Assembling Peptide Hydrogels
(Mary Ann Liebert Inc, 2015)Heparin-binding insulin-like growth factor 1 (HB-IGF-1) is a fusion protein of IGF-1 with the HB domain of heparin-binding epidermal growth factor-like growth factor. A single dose of HB-IGF-1 has been shown to bind ... -
Development, specification, and diversity of callosal projection neurons
(Elsevier, 2011)Callosal projection neurons (CPN) are a diverse population of neocortical projection neurons that connect the two hemispheres of the cerebral cortex via the corpus callosum. They play key roles in high-level associative ... -
Developmental Controls are Re-Expressed during Induction of Neurogenesis in the Neocortex of Young Adult Mice
(Frontiers Research Foundation, 2012)Whether induction of low-level neurogenesis in normally non-neurogenic regions of the adult brain mimics aspects of developmental neurogenesis is currently unknown. Previously, we and others identified that biophysically ... -
DHODH modulates transcriptional elongation in the neural crest and melanoma
(Nature Publishing Group, 2011) -
Differential Gene and Transcript Expression Analysis of RNA-seq Experiments with TopHat and Cufflinks
(Nature Publishing Group, 2012)Recent advances in high-throughput cDNA sequencing (RNA-seq) can reveal new genes and splice variants and quantify expression genome-wide in a single assay. The volume and complexity of data from RNA-seq experiments ... -
Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human
(Nature Publishing Group, 2009)We developed a digital RNA allelotyping method for quantitatively interrogating allele-specific gene expression. This method involves ultra-deep sequencing of padlock captured SNPs from the transcriptome. We characterized ... -
Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors
(Elsevier BV, 2012)Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study we show that ...