Browsing FAS Scholarly Articles by Title
Now showing items 15043-15062 of 18292
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Single and Double Photoionization from Dipole Response Function
(American Physical Society, 1997)A method for including the correlated motion of the electrons in the calculation of single and double ionization of atomic and molecular systems by the absorption of a single photon is described. The correlated dipole ... -
Single cell imaging of Bruton's Tyrosine Kinase using an irreversible inhibitor
(Nature Publishing Group, 2014)A number of Bruton's tyrosine kinase (BTK) inhibitors are currently in development, yet it has been difficult to visualize BTK expression and pharmacological inhibition in vivo in real time. We synthesized a fluorescent, ... -
Single cell resolution in vivo imaging of DNA damage following PARP inhibition
(Nature Publishing Group, 2015)Targeting DNA repair pathways is a powerful strategy to treat cancers. To gauge efficacy in vivo, typical response markers include late stage effects such as tumor shrinkage, progression free survival, or invasive repeat ... -
Single cell RNA Seq reveals dynamic paracrine control of cellular variation
(2014)High-throughput single-cell transcriptomics offers an unbiased approach for understanding the extent, basis, and function of gene expression variation between seemingly identical cells. Here, we sequence single-cell RNA-Seq ... -
Single Cell Transcriptome Amplification with MALBAC
(Public Library of Science (PLoS), 2015)Recently, Multiple Annealing and Looping-Based Amplification Cycles (MALBAC) has been developed for whole genome amplification of an individual cell, relying on quasilinear instead of exponential amplification to achieve ... -
Single Dose of a Dopamine Agonist Impairs Reinforcement Learning in Humans: Behavioral Evidence from a Laboratory-based Measure of Reward Responsiveness
(Springer Verlag, 2008)Rationale. The dopaminergic system, particularly D2-like dopamine receptors, has been strongly implicated in reward processing. Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related ... -
Single Dose of a Dopamine Agonist Impairs Reinforcement Learning in Humans: Evidence from Event-related Potentials and Computational Modeling of Striatal-Cortical Function
(Wiley-Blackwell, 2009)Animal findings have highlighted the modulatory role of phasic dopamine (DA) signaling in incentive learning, particularly in the acquisition of reward-related behavior. In humans, these processes remain largely unknown. ... -
A Single Dose of Nicotine Enhances Reward Responsiveness in Nonsmokers: Implications for Development of Dependence
(Elsevier, 2008)Background: Tobacco smoking, driven by the addictive properties of nicotine, is the most prevalent preventable cause of death in the Western world. Accumulated evidence suggests that nicotine may increase appetitive ... -
A single glycan on IgE is indispensable for initiation of anaphylaxis
(The Rockefeller University Press, 2015)Immunoglobulin ε (IgE) antibodies are the primary mediators of allergic diseases, which affect more than 1 in 10 individuals worldwide. IgE specific for innocuous environmental antigens, or allergens, binds and sensitizes ... -
Single Molecule Detection of Direct, Homologous, DNA/DNA Pairing
(National Academy of Sciences, 2009)Using a parallel single molecule magnetic tweezers assay we demonstrate homologous pairing of two double-stranded (ds) DNA molecules in the absence of proteins, divalent metal ions, crowding agents, or free DNA ends. Pairing ... -
Single Molecule Imaging of Transcription Factor Binding to DNA in Live Mammalian Cells
(Nature Publishing Group, 2013)Imaging single fluorescent proteins in living mammalian cells is challenged by out-of-focus fluorescence excitation. To reduce out-of-focus fluorescence we developed reflected light-sheet microscopy (RLSM), a fluorescence ... -
Single particle detection in CMOS compatible photonic crystal nanobeam cavities
(Optical Society of America, 2013)We report the label-free detection of single particles using photonic crystal nanobeam cavities fabricated in silicon-on-insulator platform, and embedded inside microfluidic channels fabricated in poly - dimethylsiloxane ... -
Single Particle, Passive Microrheology in Biological Fluids with Drift
Volume limitations and low yield thresholds of biological fluids have led to widespread use of passive microparticle rheology. The mean-squared-displacement (MSD) statistics of bead position time series (bead paths) are ... -
Single Vortex Pinning and Penetration Depth in Superconducting NdFeAsO1-xFx
(American Physical Society (APS), 2015)We use a magnetic force microscope (MFM) to investigate single vortex pinning and penetration depth in NdFeAsO1−xFx, one of the highest-Tc iron-based superconductors. In fields up to 20 Gauss, we observe a disordered vortex ... -
Single-Band Model of Resonant Inelastic X-Ray Scattering by Quasiparticles in High-Tc Cuprate Superconductors
(American Physical Society (APS), 2014)We show that a simple model of noninteracting quasiparticles accurately describes resonant inelastic x-ray scattering (RIXS) experiments in the hole-doped cuprate superconductors. Band structure alone yields signatures ... -
Single-cell analysis of circadian dynamics in tissue explants
(The American Society for Cell Biology, 2015)Tracking molecular dynamics in single cells in vivo is instrumental to understanding how cells act and interact in tissues. Current tissue imaging approaches focus on short-term observation and typically nonendogenous or ... -
Single-cell behavior
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The single-cell chemostat: an agarose-based, microfluidic device for high-throughput, single-cell studies of bacteria and bacterial communities
(Royal Society of Chemistry (RSC), 2012)Optical microscopy of single bacteria growing on solid agarose support is a powerful method for studying the natural heterogeneity in growth and gene expression. While the material properties of agarose make it an excellent ... -
Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state
(2015)Chromatin profiling provides a versatile means to investigate functional genomic elements and their regulation. However, current methods yield ensemble profiles that are insensitive to cell-to-cell variation. Here we combine ...